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Role of AC-cAMP-PKA Cascade in Antidepressant Action of Electroacupuncture Treatment in Rats
Joint Authors
Fu, Wen-bin
Liu, Jian-hua
Sun, Jian
Jiang, Li
Jiang, Shuo
Fu, Wen-bin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Adenylyl cyclase (AC)-cyclic adenosine monophosphate (cAMP)-cAMP-dependent protein kinase A (PKA) cascade is considered to be associated with the pathogenesis and treatment of depression.
The present study was conducted to explore the role of the cAMP cascade in antidepressant action of electroacupuncture (EA) treatment for chronic mild stress (CMS)-induced depression model rats.
The results showed that EA improved significantly behavior symptoms in depression and dysfunction of AC-cAMP-PKA signal transduction pathway induced by CMS, which was as effective as fluoxetine.
Moreover, the antidepressant effects of EA rather than Fluoxetine were completely abolished by H89, a specific PKA inhibitor.
Consequently, EA has a significant antidepressant treatment in CMS-induced depression model rats, and AC-cAMP-PKA signal transduction pathway is crucial for it.
American Psychological Association (APA)
Liu, Jian-hua& Fu, Wen-bin& Sun, Jian& Jiang, Li& Jiang, Shuo& Fu, Wen-bin. 2012. Role of AC-cAMP-PKA Cascade in Antidepressant Action of Electroacupuncture Treatment in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028630
Modern Language Association (MLA)
Liu, Jian-hua…[et al.]. Role of AC-cAMP-PKA Cascade in Antidepressant Action of Electroacupuncture Treatment in Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1028630
American Medical Association (AMA)
Liu, Jian-hua& Fu, Wen-bin& Sun, Jian& Jiang, Li& Jiang, Shuo& Fu, Wen-bin. Role of AC-cAMP-PKA Cascade in Antidepressant Action of Electroacupuncture Treatment in Rats. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028630
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028630