Paeonol Protects Memory after Ischemic Stroke via Inhibiting β-Secretase and Apoptosis
Joint Authors
Cheng, Chin-Yi
Su, Shan-Yu
Hsieh, Ching-Liang
Tsai, Tung-Hu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Poststroke dementia commonly occurs following stroke, with its pathogenesis related to β-amyloid production and apoptosis.
The present study evaluate the effects of paeonol, one of the phenolic phytochemicals isolated from the Chinese herb Paeonia suffruticosa Andrews (MC), on protection from memory loss after ischemic stroke in the subacute stage.
Rats were subjected to transient middle cerebral artery occlusion (tMCAo) with 10 min of ischemia.
The data revealed that paeonol recovered the step-through latency in the retrieval test seven days after tMCAo, but did not improve the neurological deficit induced by tMCAo.
Levels of Amyloid precursor protein (APP)- and beta-site APP cleaving enzyme (BACE; β-secretase)-immunoreactivecells, and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL)-positive cells decreased in the paeonol-administered group.
Western blotting revealed decreased levels of Bax protein in mitochondria and apoptosis-inducing factor (AIF) in cytosol following paeonol treatment.
In conclusion, we speculate that paeonol protected memory after ischemic stroke via reducing APP, BACE, and apoptosis.
Supression the level of Bax and blocking the release of AIF into cytosol might participate in the anti-apoptosis provided by paeonol.
American Psychological Association (APA)
Su, Shan-Yu& Cheng, Chin-Yi& Tsai, Tung-Hu& Hsieh, Ching-Liang. 2011. Paeonol Protects Memory after Ischemic Stroke via Inhibiting β-Secretase and Apoptosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028631
Modern Language Association (MLA)
Su, Shan-Yu…[et al.]. Paeonol Protects Memory after Ischemic Stroke via Inhibiting β-Secretase and Apoptosis. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1028631
American Medical Association (AMA)
Su, Shan-Yu& Cheng, Chin-Yi& Tsai, Tung-Hu& Hsieh, Ching-Liang. Paeonol Protects Memory after Ischemic Stroke via Inhibiting β-Secretase and Apoptosis. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028631
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028631