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3,4-Dicaffeoylquinic Acid, a Major Constituent of Brazilian Propolis, Increases TRAIL Expression and Extends the Lifetimes of Mice Infected with the Influenza A Virus
Joint Authors
Urushisaki, Tomohiko
Fukuoka, Mayuko
Hosokawa-Muto, Junji
Hata, Taketoshi
Okuda, Yumiko
Hori, Sachie
Araki, Yoko
Kuwata, Kazuo
Tazawa, Shigemi
Takemura, Tomoaki
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Brazilian green propolis water extract (PWE) and its chemical components, caffeoylquinic acids, such as 3,4-dicaffeoylquinic acid (3,4-diCQA), act against the influenza A virus (IAV) without influencing the viral components.
Here, we evaluated the anti-IAV activities of these compounds in vivo.
PWE or PEE (Brazilian green propolis ethanol extract) at a dose of 200 mg/kg was orally administered to Balb/c mice that had been inoculated with IAV strain A/WSN/33.
The lifetimes of the PWE-treated mice were significantly extended compared to the untreated mice.
Moreover, oral administration of 3,4-diCQA, a constituent of PWE, at a dose of 50 mg/kg had a stronger effect than PWE itself.
We found that the amount of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mRNA in the mice that were administered 3,4-diCQA was significantly increased compared to the control group, while H1N1 hemagglutinin (HA) mRNA was slightly decreased.
These data indicate that PWE, PEE or 3,4-diCQA possesses a novel and unique mechanism of anti-influenza viral activity, that is, enhancing viral clearance by increasing TRAIL.
American Psychological Association (APA)
Takemura, Tomoaki& Urushisaki, Tomohiko& Fukuoka, Mayuko& Hosokawa-Muto, Junji& Hata, Taketoshi& Okuda, Yumiko…[et al.]. 2011. 3,4-Dicaffeoylquinic Acid, a Major Constituent of Brazilian Propolis, Increases TRAIL Expression and Extends the Lifetimes of Mice Infected with the Influenza A Virus. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028640
Modern Language Association (MLA)
Takemura, Tomoaki…[et al.]. 3,4-Dicaffeoylquinic Acid, a Major Constituent of Brazilian Propolis, Increases TRAIL Expression and Extends the Lifetimes of Mice Infected with the Influenza A Virus. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1028640
American Medical Association (AMA)
Takemura, Tomoaki& Urushisaki, Tomohiko& Fukuoka, Mayuko& Hosokawa-Muto, Junji& Hata, Taketoshi& Okuda, Yumiko…[et al.]. 3,4-Dicaffeoylquinic Acid, a Major Constituent of Brazilian Propolis, Increases TRAIL Expression and Extends the Lifetimes of Mice Infected with the Influenza A Virus. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028640
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028640