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Rhein Induces Apoptosis in Human Breast Cancer Cells
Joint Authors
Chan, Hong-Lin
Way, Tzong-Der
Song, Ming-Zhang
Lin, Ying-Ju
Lin, Cheng-Wen
Chang, Ching-Yao
Kao, Ming-Ching
Lin, Hui-Yi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Human breast cancers cells overexpressing HER2/neu are more aggressive tumors with poor prognosis, and resistance to chemotherapy.
This study investigates antiproliferation effects of anthraquinone derivatives of rhubarb root on human breast cancer cells.
Of 7 anthraquinone derivatives, only rhein showed antiproliferative and apoptotic effects on both HER2-overexpressing MCF-7 (MCF-7/HER2) and control vector MCF-7 (MCF-7/VEC) cells.
Rhein induced dose- and time-dependent manners increase in caspase-9-mediated apoptosis correlating with activation of ROS-mediated activation of NF-κB- and p53-signaling pathways in both cell types.
Therefore, this study highlighted rhein as processing anti-proliferative activity against HER2 overexpression or HER2-basal expression in breast cancer cells and playing important roles in apoptotic induction of human breast cancer cells.
American Psychological Association (APA)
Chang, Ching-Yao& Chan, Hong-Lin& Lin, Hui-Yi& Way, Tzong-Der& Kao, Ming-Ching& Song, Ming-Zhang…[et al.]. 2011. Rhein Induces Apoptosis in Human Breast Cancer Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028644
Modern Language Association (MLA)
Chang, Ching-Yao…[et al.]. Rhein Induces Apoptosis in Human Breast Cancer Cells. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028644
American Medical Association (AMA)
Chang, Ching-Yao& Chan, Hong-Lin& Lin, Hui-Yi& Way, Tzong-Der& Kao, Ming-Ching& Song, Ming-Zhang…[et al.]. Rhein Induces Apoptosis in Human Breast Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028644
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028644