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Application of Metabolomics in Traditional Chinese Medicine Differentiation of Deficiency and Excess Syndromes in Patients with Diabetes Mellitus
Joint Authors
Wei, Hua-Feng
He, Song-Hua
Wang, Shun-Chun
Yang, Ming
Wu, Tao
Ji, Guang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Metabolic profiling is widely used as a probe in diagnosing diseases.
In this study, the metabolic profiling of urinary carbohydrates was investigated using gas chromatography/mass spectrometry (GC/MS) and multivariate statistical analysis.
The kernel-based orthogonal projections to latent structures (K-OPLS) model were established and validated to distinguish between subjects with and without diabetes mellitus (DM).
The model was combined with subwindow permutation analysis (SPA) in order to extract novel biomarker information.
Furthermore, the K-OPLS model visually represented the alterations in urinary carbohydrate profiles of excess and deficiency syndromes in patients with diabetes.
The combination of GC/MS and K-OPLS/SPA analysis allowed the urinary carbohydrate metabolic characterization of DM patients with different traditional Chinese medicine (TCM) syndromes, including biomarkers different from non-DM patients.
The method presented in this study might be a complement or an alternative to TCM syndrome research.
American Psychological Association (APA)
Wu, Tao& Yang, Ming& Wei, Hua-Feng& He, Song-Hua& Wang, Shun-Chun& Ji, Guang. 2012. Application of Metabolomics in Traditional Chinese Medicine Differentiation of Deficiency and Excess Syndromes in Patients with Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028656
Modern Language Association (MLA)
Wu, Tao…[et al.]. Application of Metabolomics in Traditional Chinese Medicine Differentiation of Deficiency and Excess Syndromes in Patients with Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1028656
American Medical Association (AMA)
Wu, Tao& Yang, Ming& Wei, Hua-Feng& He, Song-Hua& Wang, Shun-Chun& Ji, Guang. Application of Metabolomics in Traditional Chinese Medicine Differentiation of Deficiency and Excess Syndromes in Patients with Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028656
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028656