Catenarin Prevents Type 1 Diabetes in Nonobese Diabetic Mice via Inhibition of Leukocyte Migration Involving the MEK6p38 and MEK7JNK Pathways
Joint Authors
Chang, Cicero Lee-Tian
Shen, Ming-Yi
Lin, Yu-Ping
Yang, Bei-Chang
Jang, Yu-Song
Chiang, Chih-Kang
Mettling, Clément
Chen, Zeng-Weng
Lin, Yea-Lih
Yang, Wen-Chin
Sheu, Joen-Rong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Inflammation contributes to leukocyte migration, termed insulitis, and β-cell loss in type 1 diabetes (T1D).
Naturally occurring anthraquinones are claimed as anti-inflammatory compounds; however, their actions are not clear.
This study aimed to investigate the effect and mechanism of catenarin on the inflammatory disease, T1D.
Catenarin and/or its anthraquinone analogs dose-dependently suppressed C-X-C chemokine receptor type 4 (CXCR4)- and C-C chemokine receptor type 5 (CCR5)-implicated chemotaxis in leukocytes.
Catenarin, the most potent anthraquinone tested in the study, prevented T1D in nonobese diabetic mice.
Mechanistic study showed that catenarin did not act on the expression of CCR5 and CXCR4.
On the contrary, catenarin inhibited CCR5- and CXCR4-mediated chemotaxis via the reduction of the phosphorylation of mitogen-activated protein kinases (p38 and JNK) and their upstream kinases (MKK6 and MKK7), and calcium mobilization.
Overall, the data demonstrate the preventive effect and molecular mechanism of action of catenarin on T1D, suggesting its novel use as a prophylactic agent in T1D.
American Psychological Association (APA)
Shen, Ming-Yi& Lin, Yu-Ping& Yang, Bei-Chang& Jang, Yu-Song& Chiang, Chih-Kang& Mettling, Clément…[et al.]. 2012. Catenarin Prevents Type 1 Diabetes in Nonobese Diabetic Mice via Inhibition of Leukocyte Migration Involving the MEK6p38 and MEK7JNK Pathways. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1028668
Modern Language Association (MLA)
Shen, Ming-Yi…[et al.]. Catenarin Prevents Type 1 Diabetes in Nonobese Diabetic Mice via Inhibition of Leukocyte Migration Involving the MEK6p38 and MEK7JNK Pathways. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-1028668
American Medical Association (AMA)
Shen, Ming-Yi& Lin, Yu-Ping& Yang, Bei-Chang& Jang, Yu-Song& Chiang, Chih-Kang& Mettling, Clément…[et al.]. Catenarin Prevents Type 1 Diabetes in Nonobese Diabetic Mice via Inhibition of Leukocyte Migration Involving the MEK6p38 and MEK7JNK Pathways. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1028668
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028668