Epimedium koreanum Nakai Water Extract Exhibits Antiviral Activity against Porcine Epidermic Diarrhea Virus In Vitro and In Vivo
Joint Authors
Ma, Jin Yeul
Yim, Nam-Hui
Yang, Hye Jin
Kim, Hyunil
Choi, Yu Jeong
Cho, Won-Kyung
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Porcine epidemic diarrhea virus (PEDV) causes diarrhea of pigs age-independently and death of young piglets, resulting in economic loss of porcine industry.
We have screened 333 natural oriental herbal medicines to search for new antiviral candidates against PEDV.
We found that two herbal extracts, KIOM 198 and KIOM 124, contain significant anti-PED viral effect.
KIOM 198 and KIOM 124 were identified as Epimedium koreanum Nakai and Lonicera japonica Thunberg, respectively.
The further plaque and CPE inhibition assay in vitro showed that KIOM 198 has much stronger antiviral activity than KIOM 124.
Additionally, KIOM 198 exhibited a similar extent of antiviral effect against other subtypes of Corona virus such as sm98 and TGE viruses.
Cytotoxicity results showed that KIOM 198 is nontoxic on the cells and suggest that it can be delivered safely for therapy.
Furthermore, when we orally administered KIOM 198 to piglets and then infected them with PEDV, the piglets did not show any disease symptoms like diarrhea and biopsy results showed clean intestine, whereas control pigs without KIOM 198 treatment exhibited PED-related severe symptoms.
These results imply that KIOM 198 contains strong antiviral activity and has a potential to be developed as an antiviral phytomedicine to treat PEDV-related diseases in pigs.
American Psychological Association (APA)
Cho, Won-Kyung& Kim, Hyunil& Choi, Yu Jeong& Yim, Nam-Hui& Yang, Hye Jin& Ma, Jin Yeul. 2012. Epimedium koreanum Nakai Water Extract Exhibits Antiviral Activity against Porcine Epidermic Diarrhea Virus In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028674
Modern Language Association (MLA)
Cho, Won-Kyung…[et al.]. Epimedium koreanum Nakai Water Extract Exhibits Antiviral Activity against Porcine Epidermic Diarrhea Virus In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028674
American Medical Association (AMA)
Cho, Won-Kyung& Kim, Hyunil& Choi, Yu Jeong& Yim, Nam-Hui& Yang, Hye Jin& Ma, Jin Yeul. Epimedium koreanum Nakai Water Extract Exhibits Antiviral Activity against Porcine Epidermic Diarrhea Virus In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028674
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028674