Combining ZHENG Theory and High-Throughput Expression Data to Predict New Effects of Chinese Herbal Formulae
Joint Authors
Li, Yixue
Guo, Zhizhong
Yu, Shuhao
Lu, Yi-Yu
Hao, Pei
Guan, Yan
Su, Shi-Bing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
ZHENG is the key theory in traditional Chinese medicine (TCM) and it is very important to find the molecular pharmacology of traditional Chinese herbal formulae.
One ZHENG is related to many diseases and the herbal formulae are aiming to ZHENG.
Therefore, many herbal formulae whose effects on a certain disease have been confirmed might also treat other diseases with the same ZHENG.
In this study, the microarrays collected from patients with QiXuXueYu ZHENG (Qi-deficiency and Blood-stasis syndrome) before treatment and after being treated with Fuzheng Huayu Capsule were analyzed by a high-throughput gene microarrays-based drug similarity comparison method, which could find the small molecules which had similar effects with Fuzheng Huayu Capsule.
Besides getting the results of anti-inflammatory and anti-fibrosis drugs which embody the known effect of Fuzheng Huayu Capsule, many other small molecules were screened out and could reflect other types of effects of this formula in treating QiXuXueYu ZHENG, including anti-hyperglycemic, anti-hyperlipidemic, hyposenstive effect.
Then we integrated this information to display the effect of Fuzheng Huayu Capsule and its potential multiple-target molecular pharmacology.
Moreover, through using clinical blood-tested data to verify our prediction, Fuzheng Huayu Capsule was proved to have effects on diabetes and dyslipidemia.
American Psychological Association (APA)
Yu, Shuhao& Guo, Zhizhong& Guan, Yan& Lu, Yi-Yu& Hao, Pei& Li, Yixue…[et al.]. 2012. Combining ZHENG Theory and High-Throughput Expression Data to Predict New Effects of Chinese Herbal Formulae. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028676
Modern Language Association (MLA)
Yu, Shuhao…[et al.]. Combining ZHENG Theory and High-Throughput Expression Data to Predict New Effects of Chinese Herbal Formulae. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028676
American Medical Association (AMA)
Yu, Shuhao& Guo, Zhizhong& Guan, Yan& Lu, Yi-Yu& Hao, Pei& Li, Yixue…[et al.]. Combining ZHENG Theory and High-Throughput Expression Data to Predict New Effects of Chinese Herbal Formulae. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028676
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028676