Nonlinearities in Drug Release Process from Polymeric Microparticles: Long-Time-Scale Behaviour

Abstract EN

A theoretical model of the drug release process from polymeric microparticles (a particular type of polymer matrix), through dispersive fractal approximation of motion, is built.

As a result, the drug release process takes place through cnoidal oscillations modes of a normalized concentration field.

This indicates that, in the case of long-time-scale evolutions, the drug particles assemble in a lattice of nonlinear oscillators occur macroscopically, through variations of drug concentration.

The model is validated by experimental results.