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Inhibition of Aldose Reductase by Gentiana lutea Extracts
Joint Authors
Reddy, Geereddy Bhanuprakash
Akileshwari, Chandrasekhar
Joksić, Gordana
Muthenna, Puppala
Nastasijević, Branislav
Petrash, J. Mark
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Accumulation of intracellular sorbitol due to increased aldose reductase (ALR2) activity has been implicated in the development of various secondary complications of diabetes.
Thus, ALR2 inhibition could be an effective strategy in the prevention or delay of certain diabetic complications.
Gentiana lutea grows naturally in the central and southern areas of Europe.
Its roots are commonly consumed as a beverage in some European countries and are also known to have medicinal properties.
The water, ethanol, methanol, and ether extracts of the roots of G.
lutea were subjected to in vitro bioassay to evaluate their inhibitory activity on the ALR2.
While the ether and methanol extracts showed greater inhibitory activities against both rat lens and human ALR2, the water and ethanol extracts showed moderate inhibitory activities.
Moreover, the ether and methanol extracts of G.
lutea roots significantly and dose-dependently inhibited sorbitol accumulation in human erythrocytes under high glucose conditions.
Molecular docking studies with the constituents commonly present in the roots of G.
lutea indicate that a secoiridoid glycoside, amarogentin, may be a potential inhibitor of ALR2.
This is the first paper that shows G.
lutea extracts exhibit inhibitory activity towards ALR2 and these results suggest that Gentiana or its constituents might be useful to prevent or treat diabetic complications.
American Psychological Association (APA)
Akileshwari, Chandrasekhar& Muthenna, Puppala& Nastasijević, Branislav& Joksić, Gordana& Petrash, J. Mark& Reddy, Geereddy Bhanuprakash. 2012. Inhibition of Aldose Reductase by Gentiana lutea Extracts. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1029075
Modern Language Association (MLA)
Akileshwari, Chandrasekhar…[et al.]. Inhibition of Aldose Reductase by Gentiana lutea Extracts. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-1029075
American Medical Association (AMA)
Akileshwari, Chandrasekhar& Muthenna, Puppala& Nastasijević, Branislav& Joksić, Gordana& Petrash, J. Mark& Reddy, Geereddy Bhanuprakash. Inhibition of Aldose Reductase by Gentiana lutea Extracts. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1029075
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029075