An Angiotensin II Type 1 Receptor Blocker Prevents Renal Injury via Inhibition of the Notch Pathway in Ins2 Akita Diabetic Mice
Joint Authors
Mezawa, Morito
Yokote, Koutaro
He, Peng
Honjo, Satoshi
Tokuyama, Hirotake
Koshizaka, Masaya
Ishikawa, Takahiro
Sato, Seiya
Tsurutani, Yuya
Ueda, Shiro
Onishi, Shunichiro
Fujimoto, Masaki
Okabe, Emiko
Saito, Yasushi
Takemoto, Minoru
Ishibashi, Ryoichi
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Recently, it has been reported that the Notch pathway is involved in the pathogenesis of diabetic nephropathy.
In this study, we investigated the activation of the Notch pathway in Ins2 Akita diabetic mouse (Akita mouse) and the effects of telmisartan, an angiotensin II type1 receptor blocker, on the Notch pathway.
The intracellular domain of Notch1 (ICN1) is proteolytically cleaved from the cell plasma membrane in the course of Notch activation.
The expression of ICN1 and its ligand, Jagged1, were increased in the glomeruli of Akita mice, especially in the podocytes.
Administration of telmisartan significantly ameliorated the expression of ICN1 and Jagged1.
Telmisartan inhibited the angiotensin II-induced increased expression of transforming growth factor β and vascular endothelial growth factor A which could directly activate the Notch signaling pathway in cultured podocytes.
Our results indicate that the telmisartan prevents diabetic nephropathy through the inhibition of the Notch pathway.
American Psychological Association (APA)
Koshizaka, Masaya& Takemoto, Minoru& Sato, Seiya& Tokuyama, Hirotake& Fujimoto, Masaki& Okabe, Emiko…[et al.]. 2012. An Angiotensin II Type 1 Receptor Blocker Prevents Renal Injury via Inhibition of the Notch Pathway in Ins2 Akita Diabetic Mice. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1029076
Modern Language Association (MLA)
Koshizaka, Masaya…[et al.]. An Angiotensin II Type 1 Receptor Blocker Prevents Renal Injury via Inhibition of the Notch Pathway in Ins2 Akita Diabetic Mice. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-1029076
American Medical Association (AMA)
Koshizaka, Masaya& Takemoto, Minoru& Sato, Seiya& Tokuyama, Hirotake& Fujimoto, Masaki& Okabe, Emiko…[et al.]. An Angiotensin II Type 1 Receptor Blocker Prevents Renal Injury via Inhibition of the Notch Pathway in Ins2 Akita Diabetic Mice. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1029076
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029076