Diabetic Inhibition of Preconditioning- and Postconditioning-Mediated Myocardial Protection against IschemiaReperfusion Injury
Joint Authors
Zhao, Xin
Cai, Lu
Yin, Xia
Zheng, Yang
Zhai, Xujie
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Ischemic preconditioning (IPC) or postconditioning (Ipost) is proved to efficiently prevent ischemia/reperfusion injuries.
Mortality of diabetic patients with acute myocardial infarction was found to be 2–6 folds higher than that of non-diabetic patients with same myocardial infarction, which may be in part due to diabetic inhibition of IPC- and Ipost-mediated protective mechanisms.
Both IPC- and Ipost-mediated myocardial protection is predominantly mediated by stimulating PI3K/Akt and associated GSK-3β pathway while diabetes-mediated pathogenic effects are found to be mediated by inhibiting PI3K/Akt and associated GSK-3β pathway.
Therefore, this review briefly introduced the general features of IPC- and Ipost-mediated myocardial protection and the general pathogenic effects of diabetes on the myocardium.
We have collected experimental evidence that indicates the diabetic inhibition of IPC- and Ipost-mediated myocardial protection.
Increasing evidence implies that diabetic inhibition of IPC- and Ipost-mediated myocardial protection may be mediated by inhibiting PI3K/Akt and associated GSK-3β pathway.
Therefore any strategy to activate PI3K/Akt and associated GSK-3β pathway to release the diabetic inhibition of both IPC and Ipost-mediated myocardial protection may provide the protective effect against ischemia/reperfusion injuries.
American Psychological Association (APA)
Yin, Xia& Zheng, Yang& Zhai, Xujie& Zhao, Xin& Cai, Lu. 2011. Diabetic Inhibition of Preconditioning- and Postconditioning-Mediated Myocardial Protection against IschemiaReperfusion Injury. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1029080
Modern Language Association (MLA)
Yin, Xia…[et al.]. Diabetic Inhibition of Preconditioning- and Postconditioning-Mediated Myocardial Protection against IschemiaReperfusion Injury. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-1029080
American Medical Association (AMA)
Yin, Xia& Zheng, Yang& Zhai, Xujie& Zhao, Xin& Cai, Lu. Diabetic Inhibition of Preconditioning- and Postconditioning-Mediated Myocardial Protection against IschemiaReperfusion Injury. Journal of Diabetes Research. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1029080
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029080