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Impact of GLP-1 Receptor Agonists on Major Gastrointestinal Disorders for Type 2 Diabetes Mellitus: A Mixed Treatment Comparison Meta-Analysis
Joint Authors
Sun, Feng
Yu, Kai
Yang, Zhirong
Zhang, Yuan
Wu, Shanshan
Ji, Linong
Shi, Luwen
Zhan, Siyan
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-25
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Aim.
We aimed to integrate evidence from all randomized controlled trials (RCTs) and assess the impact of different doses of exenatide or liraglutide on major gastrointestinal adverse events (GIAEs) in type 2 diabetes (T2DM).
Methods.
RCTs evaluating different doses of exenatide and liraglutide against placebo or an active comparator with treatment duration ≥4 weeks were searched and reviewed.
A total of 35, 32 and 28 RCTs met the selection criteria evaluated for nausea, vomiting, and diarrhea, respectively.
Pairwise random-effects meta-analyses and mixed treatment comparisons (MTC) of all RCTs were performed.
Results.
All GLP-1 dose groups significantly increased the probability of nausea, vomiting and diarrhea relative to placebo and conventional treatment.
MTC meta-analysis showed that there was 99.2% and 85.0% probability, respectively, that people with exenatide 10 μg twice daily (EX10BID) was more vulnerable to nausea and vomiting than those with other treatments.
There was a 78.90% probability that liraglutide 1.2 mg once daily (LIR1.2) has a higher risk of diarrhea than other groups.
A dose-dependent relationship of exenatide and liraglutide on GIAEs was observed.
Conclusions.
Our MTC meta-analysis suggests that patients should be warned about these GIAEs in early stage of treatment by GLP-1s, especially by EX10BID and LIR1.2, to promote treatment compliance.
American Psychological Association (APA)
Sun, Feng& Yu, Kai& Yang, Zhirong& Wu, Shanshan& Zhang, Yuan& Shi, Luwen…[et al.]. 2012. Impact of GLP-1 Receptor Agonists on Major Gastrointestinal Disorders for Type 2 Diabetes Mellitus: A Mixed Treatment Comparison Meta-Analysis. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1029081
Modern Language Association (MLA)
Sun, Feng…[et al.]. Impact of GLP-1 Receptor Agonists on Major Gastrointestinal Disorders for Type 2 Diabetes Mellitus: A Mixed Treatment Comparison Meta-Analysis. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-1029081
American Medical Association (AMA)
Sun, Feng& Yu, Kai& Yang, Zhirong& Wu, Shanshan& Zhang, Yuan& Shi, Luwen…[et al.]. Impact of GLP-1 Receptor Agonists on Major Gastrointestinal Disorders for Type 2 Diabetes Mellitus: A Mixed Treatment Comparison Meta-Analysis. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1029081
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029081