Endoplasmic Reticulum Stress-Related Factors Protect against Diabetic Retinopathy
Joint Authors
Li, Bin
Liu, Rong
Hu, Wei-Kun
Pei, Han
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The endoplasmic reticulum (ER) is a principal mediator of signal transduction in the cell, and disruption of its normal function (a mechanism known as ER stress) has been associated with the pathogenesis of several diseases.
ER stress has been demonstrated to contribute to onset and progression of diabetic retinopathy (DR) by induction of multiple inflammatory signaling pathways.
Recent studies have begun to describe the gene expression profile of ER stress-related genes in DR; moreover, genes that play a protective role against DR have been identified.
P58IPK was determined to be able to reduce retinal vascular leakage under high glucose conditions, thus protecting retinal cells.
It has also been found by our lab that ER-associated protein degradation factors exhibit significantly different expression patterns in rat retinas under sustained high glucose conditions.
Future research based upon these collective genomic findings will contribute to our overall understanding of DR pathogenesis as well as identify potential therapeutic targets.
American Psychological Association (APA)
Hu, Wei-Kun& Liu, Rong& Pei, Han& Li, Bin. 2011. Endoplasmic Reticulum Stress-Related Factors Protect against Diabetic Retinopathy. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1029083
Modern Language Association (MLA)
Hu, Wei-Kun…[et al.]. Endoplasmic Reticulum Stress-Related Factors Protect against Diabetic Retinopathy. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-1029083
American Medical Association (AMA)
Hu, Wei-Kun& Liu, Rong& Pei, Han& Li, Bin. Endoplasmic Reticulum Stress-Related Factors Protect against Diabetic Retinopathy. Journal of Diabetes Research. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1029083
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029083