Inhibition of Protein Tyrosine Phosphatase Improves Angiogenesis via Enhancing Ang-1Tie-2 Signaling in Diabetes
Joint Authors
Liao, Duan-Fang
Tuo, Qinhui
Chen, Jian-Xiong
Zeng, Heng
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetes is associated with impairment of angiogenesis such as reduction of myocardial capillary formation.
Our previous studies demonstrate that disruption of Angiopoietin-1 (Ang-1)/Tie-2 signaling pathway contributes to the diabetes-associated impairment of angiogenesis.
Protein tyrosine phosphatase (PTP) has a critical role in the regulation of insulin signal by inhibition of tyrosine kinase phosphorylation.
In present study, we examined the role of protein tyrosine phosphatase-1 (SHP-1) in diabetes-associated impairment of Ang-1/Tie-2 angiogenic signaling and angiogenesis.
SHP-1 expression was significantly increased in diabetic db/db mouse hearts.
Furthermore, SHP-1 bond to Tie-2 receptor and stimulation with Ang-1 led to SHP-1 dissociation from Tie-2 in mouse heart microvascular endothelial cell (MHMEC).
Exposure of MHMEC to high glucose (HG, 30 mmol/L) increased SHP-1/Tie-2 association accompanied by a significant reduction of Tie-2 phosphorylation.
Exposure of MHMEC to HG also blunted Ang-1-mediated SHP-1/Tie-2 dissociation.
Knockdown of SHP-1 significantly attenuated HG-induced caspase-3 activation and apoptosis in MHMEC.
Treatment with PTP inhibitors restored Ang-1-induced Akt/eNOS phosphorylation and angiogenesis.
Our data implicate a critical role of SHP-1 in diabetes-associated vascular complications, and that upregulation of Ang-1/Tie-2 signaling by targeting SHP-1 should be considered as a new therapeutic strategy for the treatment of diabetes-associated impairment of angiogenesis.
American Psychological Association (APA)
Chen, Jian-Xiong& Tuo, Qinhui& Liao, Duan-Fang& Zeng, Heng. 2012. Inhibition of Protein Tyrosine Phosphatase Improves Angiogenesis via Enhancing Ang-1Tie-2 Signaling in Diabetes. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1029090
Modern Language Association (MLA)
Chen, Jian-Xiong…[et al.]. Inhibition of Protein Tyrosine Phosphatase Improves Angiogenesis via Enhancing Ang-1Tie-2 Signaling in Diabetes. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-1029090
American Medical Association (AMA)
Chen, Jian-Xiong& Tuo, Qinhui& Liao, Duan-Fang& Zeng, Heng. Inhibition of Protein Tyrosine Phosphatase Improves Angiogenesis via Enhancing Ang-1Tie-2 Signaling in Diabetes. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1029090
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029090