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Circulating Levels of MicroRNA from Children with Newly Diagnosed Type 1 Diabetes and Healthy Controls: Evidence That miR-25 Associates to Residual Beta-Cell Function and Glycaemic Control during Disease Progression
Joint Authors
Mortensen, Henrik B.
Juul, Anders
Hougaard, Philip
Andersen, Marie-Louise M.
Wang, Cheng
Sørensen, Kaspar
Bang-Berthelsen, Claus H.
Zhang, Chen-Yu
Nielsen, Lotte B.
Pociot, Flemming
Hansen, Lars
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study aims to identify key miRNAs in circulation, which predict ongoing beta-cell destruction and regeneration in children with newly diagnosed Type 1 Diabetes (T1D).
We compared expression level of sera miRNAs from new onset T1D children and age-matched healthy controls and related the miRNAs expression levels to beta-cell function and glycaemic control.
Global miRNA sequencing analyses were performed on sera pools from two T1D cohorts (n = 275 and 129, resp.) and one control group (n = 151).
We identified twelve upregulated human miRNAs in T1D patients (miR-152, miR-30a-5p, miR-181a, miR-24, miR-148a, miR-210, miR-27a, miR-29a, miR-26a, miR-27b, miR-25, miR-200a); several of these miRNAs were linked to apoptosis and beta-cell networks.
Furthermore, we identified miR-25 as negatively associated with residual beta-cell function (est.: −0.12, P = 0.0037), and positively associated with glycaemic control (HbA1c) (est.: 0.11, P = 0.0035) 3 months after onset.
In conclusion this study demonstrates that miR-25 might be a “tissue-specific” miRNA for glycaemic control 3 months after diagnosis in new onset T1D children and therefore supports the role of circulating miRNAs as predictive biomarkers for tissue physiopathology and potential intervention targets.
American Psychological Association (APA)
Nielsen, Lotte B.& Wang, Cheng& Sørensen, Kaspar& Bang-Berthelsen, Claus H.& Hansen, Lars& Andersen, Marie-Louise M.…[et al.]. 2012. Circulating Levels of MicroRNA from Children with Newly Diagnosed Type 1 Diabetes and Healthy Controls: Evidence That miR-25 Associates to Residual Beta-Cell Function and Glycaemic Control during Disease Progression. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029092
Modern Language Association (MLA)
Nielsen, Lotte B.…[et al.]. Circulating Levels of MicroRNA from Children with Newly Diagnosed Type 1 Diabetes and Healthy Controls: Evidence That miR-25 Associates to Residual Beta-Cell Function and Glycaemic Control during Disease Progression. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-1029092
American Medical Association (AMA)
Nielsen, Lotte B.& Wang, Cheng& Sørensen, Kaspar& Bang-Berthelsen, Claus H.& Hansen, Lars& Andersen, Marie-Louise M.…[et al.]. Circulating Levels of MicroRNA from Children with Newly Diagnosed Type 1 Diabetes and Healthy Controls: Evidence That miR-25 Associates to Residual Beta-Cell Function and Glycaemic Control during Disease Progression. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029092
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029092