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Non-MHC Risk Alleles in Rheumatoid Arthritis and in the Syntenic Chromosome Regions of Corresponding Animal Models
Joint Authors
Besenyei, Timea
Rauch, Tibor A.
Tryniszewska, Beata
Kurko, Julia
Mikecz, K.
Szekanecz, Zoltan
Kadar, Andras
Glant, T. T.
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-06
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Rheumatoid arthritis (RA) is a polygenic autoimmune disease primarily affecting the synovial joints.
Numerous animal models show similarities to RA in humans; some of them not only mimic the clinical phenotypes but also demonstrate the involvement of homologous genomic regions in RA.
This paper compares corresponding non-MHC genomic regions identified in rodent and human genome-wide association studies (GWAS).
To date, over 30 non-MHC RA-associated loci have been identified in humans, and over 100 arthritis-associated loci have been identified in rodent models of RA.
The genomic regions associated with the disease are designated by the name(s) of the gene having the most frequent and consistent RA-associated SNPs or a function suggesting their involvement in inflammatory or autoimmune processes.
Animal studies on rats and mice preferentially have used single sequence length polymorphism (SSLP) markers to identify disease-associated qualitative and quantitative trait loci (QTLs) in the genome of F2 hybrids of arthritis-susceptible and arthritis-resistant rodent strains.
Mouse GWAS appear to be far ahead of rat studies, and significantly more mouse QTLs correspond to human RA risk alleles.
American Psychological Association (APA)
Besenyei, Timea& Kadar, Andras& Tryniszewska, Beata& Kurko, Julia& Rauch, Tibor A.& Glant, T. T.…[et al.]. 2012. Non-MHC Risk Alleles in Rheumatoid Arthritis and in the Syntenic Chromosome Regions of Corresponding Animal Models. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1029098
Modern Language Association (MLA)
Besenyei, Timea…[et al.]. Non-MHC Risk Alleles in Rheumatoid Arthritis and in the Syntenic Chromosome Regions of Corresponding Animal Models. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-1029098
American Medical Association (AMA)
Besenyei, Timea& Kadar, Andras& Tryniszewska, Beata& Kurko, Julia& Rauch, Tibor A.& Glant, T. T.…[et al.]. Non-MHC Risk Alleles in Rheumatoid Arthritis and in the Syntenic Chromosome Regions of Corresponding Animal Models. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1029098
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029098