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The Role of Regulatory T Cells and TH17 Cells in Multiple Myeloma
Joint Authors
Atanackovic, Djordje
Braga, Walter M. T.
Colleoni, Gisele W. B.
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-27
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The development of multiple myeloma (MM) involves a series of genetic alterations and changes in the bone marrow microenvironment, favoring the growth of the tumor and failure of local immune control.
Quantitative and functional alterations in CD4+ and CD8+ T cells have been described in MM.
The balance between T regulatory cells (Treg) and T helper (Th) 17 cells represents one essential prerequisite for maintaining anti-tumor immunity in MM.
Tregs play an important role in the preservation of self-tolerance and modulation of overall immune responses against infections and tumor cells.
In MM patients, Tregs seem to contribute to myeloma-related immune dysfunction and targeting them could, therefore, help to restore and enhance vital immune responses.
Th17 cells protect against fungal and parasitic infections and participate in inflammatory reactions and autoimmunity.
The interplay of TGF-β and IL-6, expressed at high levels in the bone marrow of myeloma patients, may affect generation of Th17 cells both directly or via other pro-inflammatory cytokines and thereby modulate antitumor immune responses.
A detailed analysis of the balance between Tregs and Th17 cells seems necessary in order to design more effective and less toxic modes of immunotherapy myeloma which still is an uncurable malignancy.
American Psychological Association (APA)
Braga, Walter M. T.& Atanackovic, Djordje& Colleoni, Gisele W. B.. 2012. The Role of Regulatory T Cells and TH17 Cells in Multiple Myeloma. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-1029099
Modern Language Association (MLA)
Braga, Walter M. T.…[et al.]. The Role of Regulatory T Cells and TH17 Cells in Multiple Myeloma. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-1029099
American Medical Association (AMA)
Braga, Walter M. T.& Atanackovic, Djordje& Colleoni, Gisele W. B.. The Role of Regulatory T Cells and TH17 Cells in Multiple Myeloma. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-1029099
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029099