The Effect of Weight Loss on Serum Mannose-Binding Lectin Levels
Joint Authors
Bruun, J. M.
Pedersen, S. B.
Thiel, Steffen
Hansen, Troels Krarup
Richelsen, B.
Høyem, P. H.
Christiansen, J. S.
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Serum levels of the mannose-binding lectin (MBL), which is an activator of the complement system, have been considered as a pathogenic factor in a broad range of diseases, and means of modulating MBL are therefore being evaluated.
In this study we examine the effects of weight loss on MBL levels, and in continuation of this if MBL is synthesized in human adipose tissue.
Methods.
36 nondiabetic obese subjects received a very low-calorie diet (VLCD) of 800 kcal/day for 8 weeks.
Blood samples were collected at baseline and after VLCD.
Furthermore, we measured MBL mRNA levels by the real-time RT-PCR on human adipose tissue compared to liver tissue.
Results.
The mean body weight was reduced from 106.3±2.6 kg to 92.8±2.4 kg, P<0.0001.
Median MBL at baseline was 746 μg/L (IQR 316–1190) versus 892 μg/L (IQR 336–1511) after 8 weeks, P=0.23.
No correlations were found between weight loss and changes in MBL (r=-0.098, P=0.57).
MBL real-time RT-PCR showed no expression of mRNA in adipose tissue, but as expected a good expression in liver tissue was seen.
Conclusions.
MBL levels are not affected by weight loss and MBL is not synthesized in human adipose tissue.
American Psychological Association (APA)
Høyem, P. H.& Bruun, J. M.& Pedersen, S. B.& Thiel, Steffen& Richelsen, B.& Christiansen, J. S.…[et al.]. 2012. The Effect of Weight Loss on Serum Mannose-Binding Lectin Levels. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-1029101
Modern Language Association (MLA)
Høyem, P. H.…[et al.]. The Effect of Weight Loss on Serum Mannose-Binding Lectin Levels. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-1029101
American Medical Association (AMA)
Høyem, P. H.& Bruun, J. M.& Pedersen, S. B.& Thiel, Steffen& Richelsen, B.& Christiansen, J. S.…[et al.]. The Effect of Weight Loss on Serum Mannose-Binding Lectin Levels. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-1029101
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029101