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Clinical Studies Applying Cytokine-Induced Killer Cells for the Treatment of Renal Cell Carcinoma
Joint Authors
Rogenhofer, Sebastian
Brossart, Peter
Hauser, Stefan
Müller, Stefan C.
Schmidt-Wolf, Ingo G. H.
Jäkel, Clara E.
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Metastatic renal cell carcinoma (RCC) seems to be resistant to conventional chemo- and radiotherapy and the general treatment regimen of cytokine therapy produces only modest responses while inducing severe side effects.
Nowadays standard of care is the treatment with VEGF-inhibiting agents or mTOR inhibition; nevertheless, immunotherapy can induce complete remissions and long-term survival in selected patients.
Among different adoptive lymphocyte therapies, cytokine-induced killer (CIK) cells have a particularly advantageous profile as these cells are easily available, have a high proliferative rate, and exhibit a high antitumor activity.
Here, we reviewed clinical studies applying CIK cells, either alone or with standard therapies, for the treatment of RCC.
The adverse events in all studies were mild, transient, and easily controllable.
In vitro studies revealed an increased antitumor activity of peripheral lymphocytes of participants after CIK cell treatment and CIK cell therapy was able to induce complete clinical responses in RCC patients.
The combination of CIK cell therapy and standard therapy was superior to standard therapy alone.
These studies suggest that CIK cell immunotherapy is a safe and competent treatment strategy for RCC patients and further studies should investigate different treatment combinations and schedules for optimal application of CIK cells.
American Psychological Association (APA)
Jäkel, Clara E.& Hauser, Stefan& Rogenhofer, Sebastian& Müller, Stefan C.& Brossart, Peter& Schmidt-Wolf, Ingo G. H.. 2012. Clinical Studies Applying Cytokine-Induced Killer Cells for the Treatment of Renal Cell Carcinoma. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029102
Modern Language Association (MLA)
Jäkel, Clara E.…[et al.]. Clinical Studies Applying Cytokine-Induced Killer Cells for the Treatment of Renal Cell Carcinoma. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-1029102
American Medical Association (AMA)
Jäkel, Clara E.& Hauser, Stefan& Rogenhofer, Sebastian& Müller, Stefan C.& Brossart, Peter& Schmidt-Wolf, Ingo G. H.. Clinical Studies Applying Cytokine-Induced Killer Cells for the Treatment of Renal Cell Carcinoma. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029102
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029102