Clinical Usefulness of the Serological Gastric Biopsy for the Diagnosis of Chronic Autoimmune Gastritis
Joint Authors
Villalta, Danilo
Tonutti, Elio
Bizzaro, Nicola
Antico, Antonio
Tampoia, Marilina
Tozzoli, Renato
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aim.
To assess the predictive value for chronic autoimmune gastritis (AIG) of the combined assay of anti-parietal-cell antibodies (PCA), anti-intrinsic-factor antibodies (IFA), anti-Helicobacter pylori (Hp) antibodies, and measurement of blood gastrin.
Methods.
We studied 181 consecutive patients with anemia, due to iron deficiency resistant to oral replacement therapy or to vitamin B12 deficiency.
Results.
83 patients (45.8%) tested positive for PCA and underwent gastroscopy with multiple gastric biopsies.
On the basis of the histological diagnosis, PCA-positive patients were divided into 4 groups: (1) 30 patients with chronic atrophic gastritis; they had high concentrations of PCA and gastrin and no detectable IFA; (2) 14 subjects with metaplastic gastric atrophy; they had high PCA, IFA, and gastrin; (3) 18 patients with nonspecific lymphocytic inflammation with increased PCA, normal gastrin levels, and absence of IFA; (4) 21 patients with multifocal atrophic gastritis with “borderline” PCA, normal gastrin, absence of IFA and presence of anti-Hp in 100% of the cases.
Conclusions.
The assay of four serological markers proved particularly effective in the diagnostic classification of gastritis and highly correlated with the histological profile.
As such, this laboratory diagnostic profile may be considered an authentic “serological biopsy.”
American Psychological Association (APA)
Antico, Antonio& Tampoia, Marilina& Villalta, Danilo& Tonutti, Elio& Tozzoli, Renato& Bizzaro, Nicola. 2012. Clinical Usefulness of the Serological Gastric Biopsy for the Diagnosis of Chronic Autoimmune Gastritis. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-1029105
Modern Language Association (MLA)
Antico, Antonio…[et al.]. Clinical Usefulness of the Serological Gastric Biopsy for the Diagnosis of Chronic Autoimmune Gastritis. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-1029105
American Medical Association (AMA)
Antico, Antonio& Tampoia, Marilina& Villalta, Danilo& Tonutti, Elio& Tozzoli, Renato& Bizzaro, Nicola. Clinical Usefulness of the Serological Gastric Biopsy for the Diagnosis of Chronic Autoimmune Gastritis. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-1029105
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029105