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Role of Dietary Long-Chain Polyunsaturated Fatty Acids in Infant Allergies and Respiratory Diseases
Joint Authors
Lim, Jia Yi
Chong, Yap-Seng
Chong, Mary Foong-Fong
Shek, Lynette P.
Soh, Shu-E
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Maternal nutrition has critical effects on the developing structures and functions of the fetus.
Malnutrition during pregnancy can result in low birth weight and small for gestational age babies, increase risk for infection, and impact the immune system.
Long-chain polyunsaturated fatty acids (PUFAs) have been reported to have immunomodulatory effects.
Decreased consumption of omega-6 PUFAs, in favor of more anti-inflammatory omega-3 PUFAs in modern diets, has demonstrated the potential protective role of omega-3 PUFAs in allergic and respiratory diseases.
In this paper, we examine the role of PUFAs consumption during pregnancy and early childhood and its influence on allergy and respiratory diseases.
PUFAs act via several mechanisms to modulate immune function.
Omega-3 PUFAs may alter the T helper (Th) cell balance by inhibiting cytokine production which in turn inhibits immunoglobulin E synthesis and Th type 2 cell differentiation.
PUFAs may further modify cellular membrane, induce eicosanoid metabolism, and alter gene expression.
These studies indicate the benefits of omega-3 PUFAs supplementation.
Nevertheless, further investigations are warranted to assess the long-term effects of omega-3 PUFAs in preventing other immune-mediated diseases, as well as its effects on the later immunodefense and health status during early growth and development.
American Psychological Association (APA)
Shek, Lynette P.& Chong, Mary Foong-Fong& Lim, Jia Yi& Soh, Shu-E& Chong, Yap-Seng. 2012. Role of Dietary Long-Chain Polyunsaturated Fatty Acids in Infant Allergies and Respiratory Diseases. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1029112
Modern Language Association (MLA)
Shek, Lynette P.…[et al.]. Role of Dietary Long-Chain Polyunsaturated Fatty Acids in Infant Allergies and Respiratory Diseases. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-1029112
American Medical Association (AMA)
Shek, Lynette P.& Chong, Mary Foong-Fong& Lim, Jia Yi& Soh, Shu-E& Chong, Yap-Seng. Role of Dietary Long-Chain Polyunsaturated Fatty Acids in Infant Allergies and Respiratory Diseases. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1029112
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029112