Rituximab-Based Treatment, HCV Replication, and Hepatic Flares
Joint Authors
Sagnelli, Caterina
Sagnelli, Evangelista
Coppola, Nicola
Pisaturo, Mariantonietta
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Rituximab, a chimeric mouse-human monoclonal antibody directed to the CD20 antigen expressed on pre-B lymphocytes and mature lymphocytes, causes a profound B-cell depletion.
Due to its peculiar characteristics, this drug has been used to treat oncohaematological diseases, B cell-related autoimmune diseases, rheumatoid arthritis, and, more recently, HCV-associated mixed cryoglobulinaemic vasculitis.
Rituximab-based treatment, however, may induce an increased replication of several viruses such as hepatitis B virus, cytomegalovirus, varicella-zoster virus, echovirus, and parvovirus B19.
Recent data suggest that rituximab-based chemotherapy induces an increase in HCV expression in hepatic cells, which may become a target for a cell-mediated immune reaction after the withdrawal of treatment and the restoration of the immune control.
Only a few small studies have investigated the occurrence of HCV reactivation and an associated hepatic flare in patients with oncohaematological diseases receiving R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone).
These studies suggest that the hepatic flares are frequently asymptomatic, but life-threatening liver failure occurs in nearly 10% of cases.
American Psychological Association (APA)
Sagnelli, Evangelista& Pisaturo, Mariantonietta& Sagnelli, Caterina& Coppola, Nicola. 2012. Rituximab-Based Treatment, HCV Replication, and Hepatic Flares. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-1029119
Modern Language Association (MLA)
Sagnelli, Evangelista…[et al.]. Rituximab-Based Treatment, HCV Replication, and Hepatic Flares. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-1029119
American Medical Association (AMA)
Sagnelli, Evangelista& Pisaturo, Mariantonietta& Sagnelli, Caterina& Coppola, Nicola. Rituximab-Based Treatment, HCV Replication, and Hepatic Flares. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-1029119
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029119