Downregulation of Hlx Closely Related to the Decreased Expressions of T-bet and Runx3 in Patients with Gastric Cancer May Be Associated with a Pathological Event Leading to the Imbalance of Th1Th2
Joint Authors
Dai, Xiaoli
Wang, Shengjun
Xu, Yan
Chen, Jianguo
Wu, Chaoyang
Gao, Jingjing
Su, Zhaoliang
Li, Yazhen
Xu, Huaxi
Zheng, Dong
Liu, Yingzhao
Tong, Jia
Zhang, Yun
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
T-bet plays an important role in immunoregulation; it induces the differentiation of Th1 together with the homeobox transcription factor gene Hlx.
Recent studies show that T-bet and Th1-associated factors are critical in regulating tumor development.
However, the contributions of Hlx in the occurrence and development of cancer remain unknown.
In this study, the Hlx, T-bet, Runx3, and IFN-γ were measured in PBMC from patients with gastric cancer and the correlation between Hlx and T-bet or IFN-γ was assessed.
The expression levels of Hlx, T-bet, and IFN-γwere significantly decreased, and there was a positive correlation between Hlx and T-bet or IFN-γ.
In addition, the Runx3 expression was also downregulated with the lower T-bet mRNA level.
These results suggested that the decreased Hlx expression was closely associated with T-bet and Runx3 downregulations and may contribute to the development of gastric cancer.
American Psychological Association (APA)
Xu, Yan& Gao, Jingjing& Su, Zhaoliang& Dai, Xiaoli& Li, Yazhen& Liu, Yingzhao…[et al.]. 2012. Downregulation of Hlx Closely Related to the Decreased Expressions of T-bet and Runx3 in Patients with Gastric Cancer May Be Associated with a Pathological Event Leading to the Imbalance of Th1Th2. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1029120
Modern Language Association (MLA)
Xu, Yan…[et al.]. Downregulation of Hlx Closely Related to the Decreased Expressions of T-bet and Runx3 in Patients with Gastric Cancer May Be Associated with a Pathological Event Leading to the Imbalance of Th1Th2. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-1029120
American Medical Association (AMA)
Xu, Yan& Gao, Jingjing& Su, Zhaoliang& Dai, Xiaoli& Li, Yazhen& Liu, Yingzhao…[et al.]. Downregulation of Hlx Closely Related to the Decreased Expressions of T-bet and Runx3 in Patients with Gastric Cancer May Be Associated with a Pathological Event Leading to the Imbalance of Th1Th2. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1029120
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029120
