Association of Intrarenal B-Cell Infiltrates with Clinical Outcome in Lupus Nephritis: A Study of 192 Cases
Joint Authors
Dai, Min
Shen, Yan
Sun, Chuan-Yin
Yang, Cheng-De
Wu, Feng-Xia
Yan, Yu-Cheng
Chen, Yi
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Lupus nephritis (LN) remains a major cause of morbidity and end-stage renal disease.
Dysfunction of B lymphocytes is thought to be important in the pathogenesis of SLE/LN.
Intrarenal B cells have been found in several forms of inflammatory kidney diseases although their role in LN renal is not well defined.
Methods.
Intrarenal B cells were analyzed in 192 renal biopsies from patients diagnosed with lupus nephritis.
Immunohistochemical staining of serial sections was performed for each LN patient using CD20, CD3, and CD21 antibodies.
Results.
Intrarenal B cells were more likely to be associated with class IV LN and were mainly distributed in the renal interstitium, with very few in the glomerulus.
The systemic lupus erythematosus disease activity index (SLEDAI), blood urea nitrogen, and serum creatinine levels were all significantly greater in the LN-B cell groups (all P<0.05).
LN renal activity and chronicity indices correlated with B-cells infiltrates (all P<0.0001).
Renal biopsies were classified into four distinct categories according to the organizational grade of inflammatory cell infiltrates.
Germinal center- (GC-) like structures were not identified in any LN biopsies.
Conclusion.
It is hypothesized that intrarenal B cells enhance immunological responses and exaggerate the local immune response to persisting autoimmune damage in the tubulointerstitium.
American Psychological Association (APA)
Shen, Yan& Sun, Chuan-Yin& Wu, Feng-Xia& Chen, Yi& Dai, Min& Yan, Yu-Cheng…[et al.]. 2012. Association of Intrarenal B-Cell Infiltrates with Clinical Outcome in Lupus Nephritis: A Study of 192 Cases. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029121
Modern Language Association (MLA)
Shen, Yan…[et al.]. Association of Intrarenal B-Cell Infiltrates with Clinical Outcome in Lupus Nephritis: A Study of 192 Cases. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-1029121
American Medical Association (AMA)
Shen, Yan& Sun, Chuan-Yin& Wu, Feng-Xia& Chen, Yi& Dai, Min& Yan, Yu-Cheng…[et al.]. Association of Intrarenal B-Cell Infiltrates with Clinical Outcome in Lupus Nephritis: A Study of 192 Cases. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029121
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029121