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Molecular Networks Involved in the Immune Control of BK Polyomavirus
Joint Authors
Petra, Hřibová
Skibova, Jelena
Wohlfartova, Mariana
Klema, Jiri
Girmanova, Eva
Irena, Brabcová
Viklicky, Ondrej
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
BK polyomavirus infection is the important cause of virus-related nephropathy following kidney transplantation.
BK virus reactivates in 30%–80% of kidney transplant recipients resulting in BK virus-related nephropathy in 1%–10% of cases.
Currently, the molecular processes associated with asymptomatic infections in transplant patients infected with BK virus remain unclear.
In this study we evaluate intrarenal molecular processes during different stages of BKV infection.
The gene expression profiles of 90 target genes known to be associated with immune response were evaluated in kidney graft biopsy material using TaqMan low density array.
Three patient groups were examined: control patients with no evidence of BK virus reactivation (n=11), infected asymptomatic patients (n=9), and patients with BK virus nephropathy (n=10).
Analysis of biopsies from asymptomatic viruria patients resulted in the identification of 5 differentially expressed genes (CD3E, CD68, CCR2, ICAM-1, and SKI) (P<0.05), and functional analysis showed a significantly heightened presence of costimulatory signals (e.g., CD40/CD40L; P<0.05).
Gene ontology analysis revealed several biological networks associated with BKV immune control in comparison to the control group.
This study demonstrated that asymptomatic BK viruria is associated with a different intrarenal regulation of several genes implicating in antiviral immune response.
American Psychological Association (APA)
Girmanova, Eva& Irena, Brabcová& Klema, Jiri& Petra, Hřibová& Wohlfartova, Mariana& Skibova, Jelena…[et al.]. 2012. Molecular Networks Involved in the Immune Control of BK Polyomavirus. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1029122
Modern Language Association (MLA)
Girmanova, Eva…[et al.]. Molecular Networks Involved in the Immune Control of BK Polyomavirus. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-1029122
American Medical Association (AMA)
Girmanova, Eva& Irena, Brabcová& Klema, Jiri& Petra, Hřibová& Wohlfartova, Mariana& Skibova, Jelena…[et al.]. Molecular Networks Involved in the Immune Control of BK Polyomavirus. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1029122
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029122