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Design and Construction of a One-Dimensional DNA Track for an Artificial Molecular Motor
Joint Authors
Kovacic, Suzana
Samii, Laleh
Woolfson, Derek N.
Curmi, Paul M. G.
Forde, Nancy R.
Blab, Gerhard A.
Linke, Heiner
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
DNA is a versatile heteropolymer that shows great potential as a building block for a diverse array of nanostructures.
We present here a solution to the problem of designing and synthesizing a DNA-based nanostructure that will serve as the track along which an artificial molecular motor processes.
This one-dimensional DNA track exhibits periodically repeating elements that provide specific binding sites for the molecular motor.
Besides these binding elements, additional sequences are necessary to label specific regions within the DNA track and to facilitate track construction.
Designing an ideal DNA track sequence presents a particular challenge because of the many variable elements that greatly expand the number of potential sequences from which the ideal sequence must be chosen.
In order to find a suitable DNA sequence, we have adapted a genetic algorithm which is well suited for a large but sparse search space.
This algorithm readily identifies long DNA sequences that include all the necessary elements to both facilitate DNA track construction and to present appropriate binding sites for the molecular motor.
We have successfully experimentally incorporated the sequence identified by the algorithm into a long DNA track meeting the criteria for observation of the molecular motor's activity.
American Psychological Association (APA)
Kovacic, Suzana& Samii, Laleh& Woolfson, Derek N.& Curmi, Paul M. G.& Linke, Heiner& Forde, Nancy R.…[et al.]. 2012. Design and Construction of a One-Dimensional DNA Track for an Artificial Molecular Motor. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1029130
Modern Language Association (MLA)
Kovacic, Suzana…[et al.]. Design and Construction of a One-Dimensional DNA Track for an Artificial Molecular Motor. Journal of Nanomaterials No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1029130
American Medical Association (AMA)
Kovacic, Suzana& Samii, Laleh& Woolfson, Derek N.& Curmi, Paul M. G.& Linke, Heiner& Forde, Nancy R.…[et al.]. Design and Construction of a One-Dimensional DNA Track for an Artificial Molecular Motor. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1029130
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029130