Antioxidant Effects of Quercetin and Catechin Encapsulated into PLGA Nanoparticles
Joint Authors
Pool, Hector
Quintanar, David
Figueroa, Juan de Dios
Marinho Mano, Camila
Bechara, J. Etelvino H.
Mendoza, Sandra
Godínez Mora-Tovar, L. A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Polymeric nanoparticles (PLGA) have been developed for the encapsulation and controlled release of quercetin and catechin.
Nanoparticles were fabricated using a solvent displacement method.
Physicochemical properties were measured by light scattering, scanning electron microscopy and ζ-potential, X-ray diffraction, infrared spectroscopy and differential scanning calorimetry.
Encapsulation efficiency and in vitro release profiles were obtained from differential pulse voltammetry experiments.
Antioxidant properties of free and encapsulated flavonoids were determined by TBARS, fluorescence spectroscopy and standard chelating activity methods.
Relatively small (d≈ 400 nm) polymeric nanoparticles were obtained containing quercetin or catechin in a non-crystalline form (EE ≈ 79%) and the main interactions between the polymer and each flavonoid were found to consist of hydrogen bonds.
In vitro release profiles were pH-dependant, the more acidic pH, the faster release of each flavonoid from the polymeric nanoparticles.
The inhibition of the action of free radicals and chelating properties, were also enhanced when quercetin and catechin were encapsulated within PLGA nanoparticles.
The information obtained from this study will facilitate the design and fabrication of polymeric nanoparticles as possible oral delivery systems for encapsulation, protection and controlled release of flavonoids aimed to prevent oxidative stress in human body or food products.
American Psychological Association (APA)
Pool, Hector& Quintanar, David& Figueroa, Juan de Dios& Marinho Mano, Camila& Bechara, J. Etelvino H.& Godínez Mora-Tovar, L. A.…[et al.]. 2012. Antioxidant Effects of Quercetin and Catechin Encapsulated into PLGA Nanoparticles. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1029140
Modern Language Association (MLA)
Pool, Hector…[et al.]. Antioxidant Effects of Quercetin and Catechin Encapsulated into PLGA Nanoparticles. Journal of Nanomaterials No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-1029140
American Medical Association (AMA)
Pool, Hector& Quintanar, David& Figueroa, Juan de Dios& Marinho Mano, Camila& Bechara, J. Etelvino H.& Godínez Mora-Tovar, L. A.…[et al.]. Antioxidant Effects of Quercetin and Catechin Encapsulated into PLGA Nanoparticles. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1029140
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029140