Fabrication and Characterization of Collagen-Immobilized Porous PHBVHA Nanocomposite Scaffolds for Bone Tissue Engineering
Joint Authors
Xing, Zhi-Cai
Baek, Jin-Young
Kwak, Giseop
Yoon, Keun-Byoung
Park, Lee Soon
Park, Soo-Young
Kang, Inn-Kyu
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The porous composite scaffolds (PHBV/HA) consisting of poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and hydroxyapatite (HA) were fabricated using a hot-press machine and salt-leaching.
Collagen (type I) was then immobilized on the surface of the porous PHBV/HA composite scaffolds to improve tissue compatibility.
The structure and morphology of the collagen-immobilized composite scaffolds (PHBV/HA/Col) were investigated using a scanning electron microscope (SEM), Fourier transform infrared (FTIR), and electron spectroscopy for chemical analysis (ESCA).
The potential of the porous PHBV/HA/Col composite scaffolds for use as a bone scaffold was assessed by an experiment with osteoblast cells (MC3T3-E1) in terms of cell adhesion, proliferation, and differentiation.
The results showed that the PHBV/HA/Col composite scaffolds possess better cell adhesion and significantly higher proliferation and differentiation than the PHBV/HA composite scaffolds and the PHBV scaffolds.
These results suggest that the PHBV/HA/Col composite scaffolds have a high potential for use in the field of bone regeneration and tissue engineering.
American Psychological Association (APA)
Baek, Jin-Young& Xing, Zhi-Cai& Kwak, Giseop& Yoon, Keun-Byoung& Park, Soo-Young& Park, Lee Soon…[et al.]. 2012. Fabrication and Characterization of Collagen-Immobilized Porous PHBVHA Nanocomposite Scaffolds for Bone Tissue Engineering. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1029146
Modern Language Association (MLA)
Baek, Jin-Young…[et al.]. Fabrication and Characterization of Collagen-Immobilized Porous PHBVHA Nanocomposite Scaffolds for Bone Tissue Engineering. Journal of Nanomaterials No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1029146
American Medical Association (AMA)
Baek, Jin-Young& Xing, Zhi-Cai& Kwak, Giseop& Yoon, Keun-Byoung& Park, Soo-Young& Park, Lee Soon…[et al.]. Fabrication and Characterization of Collagen-Immobilized Porous PHBVHA Nanocomposite Scaffolds for Bone Tissue Engineering. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1029146
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029146