In Vitro Assessment of Antibacterial Activity and Cytocompatibility of Quercetin-Containing PLGA Nanofibrous Scaffolds for Tissue Engineering
Joint Authors
Xing, Zhi-Cai
Meng, Wan
Yuan, Jiang
Moon, Sungmo
Jeong, Yongsoo
Kang, Inn-Kyu
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Flavonoids, such as quercetin, have been reported to exhibit a wide range of biological activities related to their antioxidant capacity.
The aim of this study was to investigate the protective effect of quercetin on cell adhesion, and the viability and proliferation of KB epithelial cells.
Quercetin- (1, 5 wt%)-containing poly (l-lactide-co-glycolide) (PLGA) nanofibrous scaffolds (PLGA/Q 1, PLGA/Q 5) were prepared by electrospinning technique and their antibacterial properties were examined.
Two types of bacteria strains, Staphylococcus aureus (SA) and Klebsiella pneumoniae (KP), were used to evaluate the antibacterial properties of the scaffolds.
The results showed that the quercetin-containing PLGA nanofibrous scaffolds exhibited significant antibacterial effects against the two bacterial strains.
KB epithelial cells were also used to evaluate the cytocompatibility of the scaffolds.
From the results, it was found that the PLGA nanofibrous scaffolds with 1 wt% of quercetin had good cell compatibility.
It is considered that the PLGA nanofibrous scaffolds with 1 wt% quercetin have potential to be used in tissue engineering.
American Psychological Association (APA)
Xing, Zhi-Cai& Meng, Wan& Yuan, Jiang& Moon, Sungmo& Jeong, Yongsoo& Kang, Inn-Kyu. 2012. In Vitro Assessment of Antibacterial Activity and Cytocompatibility of Quercetin-Containing PLGA Nanofibrous Scaffolds for Tissue Engineering. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029157
Modern Language Association (MLA)
Xing, Zhi-Cai…[et al.]. In Vitro Assessment of Antibacterial Activity and Cytocompatibility of Quercetin-Containing PLGA Nanofibrous Scaffolds for Tissue Engineering. Journal of Nanomaterials No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1029157
American Medical Association (AMA)
Xing, Zhi-Cai& Meng, Wan& Yuan, Jiang& Moon, Sungmo& Jeong, Yongsoo& Kang, Inn-Kyu. In Vitro Assessment of Antibacterial Activity and Cytocompatibility of Quercetin-Containing PLGA Nanofibrous Scaffolds for Tissue Engineering. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029157
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029157