Characterization and Antiproliferative Activity of Nobiletin-Loaded Chitosan Nanoparticles
Joint Authors
Luque-Alcaraz, Ana G.
Lizardi, Jaime
Goycoolea, Francisco M.
Valdez, Miguel A.
Iloki-Assanga, Simon B.
Higuera-Ciapara, Inocencio
Argüelles-Monal, Waldo
Acosta, Ana
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Nobiletin is a polymethoxyflavonoid with a remarkable antiproliferative effect.
In order to overcome its low aqueous solubility and chemical instability, the use of nanoparticles as carriers has been proposed.
This study explores the possibility of binding nobiletin to chitosan nanoparticles, as well as to evaluate their antiproliferative activity.
The association and loading efficiencies are 69.1% and 7.0%, respectively.
The formation of an imine bond between chitosan amine groups and the carbonyl group of nobiletin, via Schiff-base, is proposed.
Nobiletin-loaded chitosan nanoparticles exhibit considerable inhibition (IC50=8 μg/mL) of cancerous cells, revealing their great potential for applications in cancer chemotherapy.
American Psychological Association (APA)
Luque-Alcaraz, Ana G.& Lizardi, Jaime& Goycoolea, Francisco M.& Valdez, Miguel A.& Acosta, Ana& Iloki-Assanga, Simon B.…[et al.]. 2012. Characterization and Antiproliferative Activity of Nobiletin-Loaded Chitosan Nanoparticles. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029172
Modern Language Association (MLA)
Luque-Alcaraz, Ana G.…[et al.]. Characterization and Antiproliferative Activity of Nobiletin-Loaded Chitosan Nanoparticles. Journal of Nanomaterials No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1029172
American Medical Association (AMA)
Luque-Alcaraz, Ana G.& Lizardi, Jaime& Goycoolea, Francisco M.& Valdez, Miguel A.& Acosta, Ana& Iloki-Assanga, Simon B.…[et al.]. Characterization and Antiproliferative Activity of Nobiletin-Loaded Chitosan Nanoparticles. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029172
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029172