![](/images/graphics-bg.png)
Chitosan Nanoparticles as a Percutaneous Drug Delivery System for Hydrocortisone
Joint Authors
Hussain, Zahid
Ling, Tay Chai
Katas, Haliza
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Hydrocortisone (HC) has formed the mainstay for the management of atopic dermatitis.
Hence, HC-loaded chitosan nanoparticles were prepared by ionic crosslinking of high, low molecular weight chitosan (HMwt, LMwt CS) and N-trimethyl chitosan (TMC) with tripolyphosphate.
HC loading into CS nanoparticles was confirmed by FT-IR.
The particle size of HC-loaded HMwt, LMwt, and TMC nanoparticles was increased from 243±12, 147±11, and 124±9 nm to 337±13, 222±14, and 195±7 nm, respectively, by increasing the pH of CS solution.
Their respective zeta potential and entrapment efficiency (EE) were significantly decreased by increasing the pH of CS solution.
The swelling ratios of HC loaded HMwt, LMwt, and TMC NPs were increased when the pH of incubating media (PBS) was increased.
The same increasing trend was observed in particle size and EE of HC loaded as the CS concentration was increased.
The HC loaded CS NPs were generally nonspherical.
In-vitro permeation studies showed that HC was efficiently released from the CS NPs in QV cream while in aqueous cream CS NPs provided a sustained release for HC.
Thus, it is anticipated that CS NPs are the promising delivery system for anti-inflammatory drugs.
American Psychological Association (APA)
Katas, Haliza& Hussain, Zahid& Ling, Tay Chai. 2012. Chitosan Nanoparticles as a Percutaneous Drug Delivery System for Hydrocortisone. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1029197
Modern Language Association (MLA)
Katas, Haliza…[et al.]. Chitosan Nanoparticles as a Percutaneous Drug Delivery System for Hydrocortisone. Journal of Nanomaterials No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1029197
American Medical Association (AMA)
Katas, Haliza& Hussain, Zahid& Ling, Tay Chai. Chitosan Nanoparticles as a Percutaneous Drug Delivery System for Hydrocortisone. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1029197
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029197