Changes in Cardiac Autonomic Regulation after Acute Lung Exposure to Carbon Nanotubes: Implications for Occupational Exposure
Joint Authors
Magrini, A.
Legramante, Jacopo M.
Sacco, Sergio
Crobeddu, Patrizio
Valentini, Federica
Palleschi, Giuseppe
Pallante, Marco
Balocchi, Rita
Bergamaschi, Antonio
Galante, Alberto
Campagnolo, Luisa
Pietroiusti, Antonio
Iavicoli, Ivo
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Carbon nanotubes (CNTs) are among the most relevant engineered nanomaterials (ENMs).
Given the expected rise of exposure to ENMs, there is concern that they may adversely affect health of exposed people.
Aim of the study was to test the hypothesis that single wall carbon nanotubes (SWCNTs) pulmonary exposure acutely affect the autonomic cardiovascular regulation in conscious rats.
We studied Wistar-Kyoto rats in which a telemetry transmitter for continuous arterial pressure (AP) and heart rate (HR) recordings was surgically implanted.
SWCNTs dispersed in phosphate buffer saline (PBS) or PBS alone were randomly administered intratracheally.
Immediately before, and 24 hours after each instillation a 30 min AP recording was performed.
The sequence analysis was performed to evaluate the baroreflex function.
In the control group, PBS instillation did not induce any significant changes.
At variance the SWCNT exposure induced a significant reduction of baroreflex system (BRS) (3.5±0.6 versus 2.6±0.40 msec/mmHg) without significant changes in the occurrence of baroreflex sequences (7.5±0.47% versus 7.4±0.38%).
Our results show that SWCNT pulmonary exposure might affect the cardiovascular autonomic regulation thus contributing to cardiac and arrhythmic events.
American Psychological Association (APA)
Legramante, Jacopo M.& Sacco, Sergio& Crobeddu, Patrizio& Magrini, A.& Valentini, Federica& Palleschi, Giuseppe…[et al.]. 2012. Changes in Cardiac Autonomic Regulation after Acute Lung Exposure to Carbon Nanotubes: Implications for Occupational Exposure. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1029203
Modern Language Association (MLA)
Legramante, Jacopo M.…[et al.]. Changes in Cardiac Autonomic Regulation after Acute Lung Exposure to Carbon Nanotubes: Implications for Occupational Exposure. Journal of Nanomaterials No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1029203
American Medical Association (AMA)
Legramante, Jacopo M.& Sacco, Sergio& Crobeddu, Patrizio& Magrini, A.& Valentini, Federica& Palleschi, Giuseppe…[et al.]. Changes in Cardiac Autonomic Regulation after Acute Lung Exposure to Carbon Nanotubes: Implications for Occupational Exposure. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1029203
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029203