Changes in Cardiac Autonomic Regulation after Acute Lung Exposure to Carbon Nanotubes: Implications for Occupational Exposure

Joint Authors

Magrini, A.
Legramante, Jacopo M.
Sacco, Sergio
Crobeddu, Patrizio
Valentini, Federica
Palleschi, Giuseppe
Pallante, Marco
Balocchi, Rita
Bergamaschi, Antonio
Galante, Alberto
Campagnolo, Luisa
Pietroiusti, Antonio
Iavicoli, Ivo

Source

Journal of Nanomaterials

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-05-08

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Chemistry
Civil Engineering

Abstract EN

Carbon nanotubes (CNTs) are among the most relevant engineered nanomaterials (ENMs).

Given the expected rise of exposure to ENMs, there is concern that they may adversely affect health of exposed people.

Aim of the study was to test the hypothesis that single wall carbon nanotubes (SWCNTs) pulmonary exposure acutely affect the autonomic cardiovascular regulation in conscious rats.

We studied Wistar-Kyoto rats in which a telemetry transmitter for continuous arterial pressure (AP) and heart rate (HR) recordings was surgically implanted.

SWCNTs dispersed in phosphate buffer saline (PBS) or PBS alone were randomly administered intratracheally.

Immediately before, and 24 hours after each instillation a 30 min AP recording was performed.

The sequence analysis was performed to evaluate the baroreflex function.

In the control group, PBS instillation did not induce any significant changes.

At variance the SWCNT exposure induced a significant reduction of baroreflex system (BRS) (3.5±0.6 versus 2.6±0.40 msec/mmHg) without significant changes in the occurrence of baroreflex sequences (7.5±0.47% versus 7.4±0.38%).

Our results show that SWCNT pulmonary exposure might affect the cardiovascular autonomic regulation thus contributing to cardiac and arrhythmic events.

American Psychological Association (APA)

Legramante, Jacopo M.& Sacco, Sergio& Crobeddu, Patrizio& Magrini, A.& Valentini, Federica& Palleschi, Giuseppe…[et al.]. 2012. Changes in Cardiac Autonomic Regulation after Acute Lung Exposure to Carbon Nanotubes: Implications for Occupational Exposure. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1029203

Modern Language Association (MLA)

Legramante, Jacopo M.…[et al.]. Changes in Cardiac Autonomic Regulation after Acute Lung Exposure to Carbon Nanotubes: Implications for Occupational Exposure. Journal of Nanomaterials No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1029203

American Medical Association (AMA)

Legramante, Jacopo M.& Sacco, Sergio& Crobeddu, Patrizio& Magrini, A.& Valentini, Federica& Palleschi, Giuseppe…[et al.]. Changes in Cardiac Autonomic Regulation after Acute Lung Exposure to Carbon Nanotubes: Implications for Occupational Exposure. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1029203

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1029203