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Properties of Surfactin C-15 Nanopeptide and Its Cytotoxic Effect on Human Cervix Cancer (HeLa) Cell Line
Joint Authors
Asadi, Asadollah
Nozhat, Zahra
Zahri, Saber
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Surfactin is one of the most powerful biosurfactants that has been known so far.
It is an acidic cyclic nonribosomal lipoheptapeptide that is produced by Bacillus subtilis.
In this presentation we investigated different properties of surfactin C-15.
The nanomicelle forming ability of surfactin C-15 in different aqueous environments with various ionic strengths was studied by scanning electron microscope.
Surfactin second structure was investigated by Far-UV CD spectrum.
Its hemolytic activity and cytotoxicity were measured by hemolysis and MTT assays, respectively.
Surfactin formed spherical nanomicelles in distilled water (pH=7.4) and amorphous nanomicelles in PBS buffer (pH=7.4).
The hemolysis assay results indicated that HC50 of surfactin was 47 μM.
Surfactin C-15 arrested growth of human cervix cancer HeLa cell line in a time- and dosage-dependent method, so that its IC50 at 16, 24, and 48h were 86.9, 73.1, and 50.2 μM, respectively.
American Psychological Association (APA)
Nozhat, Zahra& Asadi, Asadollah& Zahri, Saber. 2012. Properties of Surfactin C-15 Nanopeptide and Its Cytotoxic Effect on Human Cervix Cancer (HeLa) Cell Line. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-1029240
Modern Language Association (MLA)
Nozhat, Zahra…[et al.]. Properties of Surfactin C-15 Nanopeptide and Its Cytotoxic Effect on Human Cervix Cancer (HeLa) Cell Line. Journal of Nanomaterials No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-1029240
American Medical Association (AMA)
Nozhat, Zahra& Asadi, Asadollah& Zahri, Saber. Properties of Surfactin C-15 Nanopeptide and Its Cytotoxic Effect on Human Cervix Cancer (HeLa) Cell Line. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-1029240
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029240