Self-Assembling Peptide Nanofiber Scaffold Enhanced with RhoA Inhibitor CT04 Improves Axonal Regrowth in the Transected Spinal Cord
Joint Authors
Zhang, Weiwei
Zhan, Xiaoduo
Gao, Mingyong
Hamilton, Audra D.
Liu, Zhongying
Jiang, Yanwen
Su, Huanxing
Dai, Xiang
He, Bin
Kang, Xiaoning
Zeng, Yuanshan
Guo, Jiasong
Wu, Wutian
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The present study was designed to explore the therapeutic potential of self-assembling peptide nanofiber scaffold (SAPNS) delivered RhoA inhibitor to ameliorate the hostile microenvironment of injured spinal cord for axonal regeneration.
After a transection was applied to the thoracic spinal cord of mice, the combination of SAPNS and CT04 (a cell permeable RhoA inhibitor), single SAPNS with vehicle, or saline was transplanted into the lesion cavity.
Results showed that SAPNS+CT04 implants achieved the best therapeutic outcomes among treatment groups.
The novel combination not only reconstructed the injured nerve gap but also elicited significant axonal regeneration and motor functional recovery.
Additionally, the combination also effectively reduced the apoptosis and infiltration of activated macrophages in the injured spinal cord.
Collectively, the present study demonstrated that SAPNS-based delivery of RhoA inhibitor CT04 presented a highly potential therapeutic strategy for spinal cord injury with reknitting lesion gap, attenuating secondary injury, and improving axonal regrowth.
American Psychological Association (APA)
Zhang, Weiwei& Zhan, Xiaoduo& Gao, Mingyong& Hamilton, Audra D.& Liu, Zhongying& Jiang, Yanwen…[et al.]. 2012. Self-Assembling Peptide Nanofiber Scaffold Enhanced with RhoA Inhibitor CT04 Improves Axonal Regrowth in the Transected Spinal Cord. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1029267
Modern Language Association (MLA)
Zhang, Weiwei…[et al.]. Self-Assembling Peptide Nanofiber Scaffold Enhanced with RhoA Inhibitor CT04 Improves Axonal Regrowth in the Transected Spinal Cord. Journal of Nanomaterials No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1029267
American Medical Association (AMA)
Zhang, Weiwei& Zhan, Xiaoduo& Gao, Mingyong& Hamilton, Audra D.& Liu, Zhongying& Jiang, Yanwen…[et al.]. Self-Assembling Peptide Nanofiber Scaffold Enhanced with RhoA Inhibitor CT04 Improves Axonal Regrowth in the Transected Spinal Cord. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1029267
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029267