Control of In Vivo Transport and Toxicity of Nanoparticles by Tea Melanin
Joint Authors
Chiou, Jun-Chern
Chen, Yu-Shiun
Hung, Yao-Ching
Hong, Meng-Yeng
Onischuk, Andrei Aleksandrovich
Sorokina, Irina V.
Tolstikova, Tatiana
Steve Huang, G.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Nanoparticles are unfamiliar to researchers in toxicology.
Toxicity may be generated simply due to the reduction in size.
Compounds that prevent or cure toxic materials may not work on nanoparticles.
Furthermore, as there are more and more applications of nanoparticles in drug delivery and in vivo imaging, controlling the transport and toxicity will be primary concerns for medical application of nanoparticles.
Gold nanoparticles (GNPs) if injected intraperitoneally into mice can enter hippocampus and induce cognitive impairment.
GNPs caused a global imbalance of monoamine levels, specifically affecting the dopaminergic and serotonergic neurons.
Pretreatment of tea melanin significantly prevented the deposition of GNPs in mouse brains, especially in the hippocampus.
Pretreatment of melanin completely alleviated GNP-induced impairment of cognition.
Pre-administration of melanin stably maintained monoamines at normal profiles.
Melanin completely prevented the invasion of GNPs into the Cornu Ammonis region of the hippocampus shown by coherent anti-Stoke Raman scattering microscopy.
Here we show that the administration of tea melanin prevented the accumulation of Au in brain, the imbalance of monoamines, and the impairment of cognition in mice.
The current study provides a therapeutic approach to toxicity of nanoparticles and a novel strategy to control the transport of GNP in mouse brain.
American Psychological Association (APA)
Chen, Yu-Shiun& Hung, Yao-Ching& Hong, Meng-Yeng& Onischuk, Andrei Aleksandrovich& Chiou, Jun-Chern& Sorokina, Irina V.…[et al.]. 2012. Control of In Vivo Transport and Toxicity of Nanoparticles by Tea Melanin. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1029269
Modern Language Association (MLA)
Chen, Yu-Shiun…[et al.]. Control of In Vivo Transport and Toxicity of Nanoparticles by Tea Melanin. Journal of Nanomaterials No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1029269
American Medical Association (AMA)
Chen, Yu-Shiun& Hung, Yao-Ching& Hong, Meng-Yeng& Onischuk, Andrei Aleksandrovich& Chiou, Jun-Chern& Sorokina, Irina V.…[et al.]. Control of In Vivo Transport and Toxicity of Nanoparticles by Tea Melanin. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1029269
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029269