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Novel Mannan-PEG-PE Modified Bioadhesive PLGA Nanoparticles for Targeted Gene Delivery
Joint Authors
Kong, Fansheng
Wu, Guicun
Liu, Ximin
Zhou, Fang
Ge, Linfu
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
Biodegradable polymeric nanoparticles have been used frequently as gene delivery vehicles.
The aim of this study is to modify bioadhesive PLGA nanoparticles with novel synthetic mannan-PEG-PE (MN-PEG-PE) to obtain active targeted gene delivery system.
Methods.
Mannan-PEG-PE ligands were synthesized and modified onto the NPs/pEGFP complexes.
The modification rate was optimized, and the characteristics of the vehicle were evaluated.
Then, the modified vectors were intravenous delivered to rats, and in vivo targeting behavior of MN-PEG-PE modified PLGA nanoparticles/pEGFP complexes (MN-PEG-PE-NPs/pEGFP) in liver macrophages was investigated.
Results.
MN-PEG-PE-NPs/pEGFP displayed remarkably higher transfection efficiencies than nonmodified NPs/pEGFP both in vitro and in vivo.
Conclusions.
Mannan containing targeting ligands could significantly improve the transfection efficiency of the carriers.
MN-PEG-PE modified vectors very useful in targeted gene delivery.
American Psychological Association (APA)
Wu, Guicun& Zhou, Fang& Ge, Linfu& Liu, Ximin& Kong, Fansheng. 2012. Novel Mannan-PEG-PE Modified Bioadhesive PLGA Nanoparticles for Targeted Gene Delivery. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1029339
Modern Language Association (MLA)
Wu, Guicun…[et al.]. Novel Mannan-PEG-PE Modified Bioadhesive PLGA Nanoparticles for Targeted Gene Delivery. Journal of Nanomaterials No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1029339
American Medical Association (AMA)
Wu, Guicun& Zhou, Fang& Ge, Linfu& Liu, Ximin& Kong, Fansheng. Novel Mannan-PEG-PE Modified Bioadhesive PLGA Nanoparticles for Targeted Gene Delivery. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1029339
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029339