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Spectroscopic Study of the Interaction of DNA with the Linker Histone H1 from Starfish Sperm Reveals Mechanisms of the Formation of Supercondensed Sperm Chromatin
Joint Authors
Polyanichko, Alexander
Chikhirzhina, Elena
Starkova, Tatyana
Kostyleva, Elena
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The interaction of the linker histone H1Z from the sperm chromatin of starfish Asterias amurensis with DNA was studied by spectroscopic and thermodynamic approaches.
It has been shown that at the physiological conditions the interaction of the H1Z with DNA results in more compact structures compared to complexes of DNA with somatic histone H1.
The typical profile of the DNA melting curves reveals two peaks attributed to the bound and unbound DNA.
It has been shown that H1Z from starfish sperm stabilizes DNA to a greater extent compared to the somatic H1.
It is possible that the presence of the additional α—helical segments within the C-terminal part of the H1Z typical for the linker histones from echinoderm sperm facilitates the protein-protein interactions which in turn stimulate cooperative binding of the histones to DNA, resulting in the formation of the supercompact sperm chromatin.
American Psychological Association (APA)
Chikhirzhina, Elena& Starkova, Tatyana& Kostyleva, Elena& Polyanichko, Alexander. 2012. Spectroscopic Study of the Interaction of DNA with the Linker Histone H1 from Starfish Sperm Reveals Mechanisms of the Formation of Supercondensed Sperm Chromatin. Journal of Spectroscopy،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1029351
Modern Language Association (MLA)
Chikhirzhina, Elena…[et al.]. Spectroscopic Study of the Interaction of DNA with the Linker Histone H1 from Starfish Sperm Reveals Mechanisms of the Formation of Supercondensed Sperm Chromatin. Journal of Spectroscopy No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1029351
American Medical Association (AMA)
Chikhirzhina, Elena& Starkova, Tatyana& Kostyleva, Elena& Polyanichko, Alexander. Spectroscopic Study of the Interaction of DNA with the Linker Histone H1 from Starfish Sperm Reveals Mechanisms of the Formation of Supercondensed Sperm Chromatin. Journal of Spectroscopy. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1029351
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029351