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Antimicrobial Peptide from the Eusocial Bee Halictus sexcinctus Interacting with Model Membranes
Joint Authors
Kočišová, E.
Bednárová, Lucie
Pazderková, Markéta
Pazderka, Tomáš
Maloň, Petr
Kopecký Jr., Vladimír
Monincová, Lenka
Čeřovský, Václav
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Halictine-1 (Hal-1)—a linear antibacterial dodecapeptide isolated from the venom of the eusocial bee Halictus sexcinctus—has been subjected to a detailed spectroscopic study including circular dichroism, fluorescence, and vibrational spectroscopy.
We investigated Hal-1 ability to adopt an amphipathic α-helical structure upon interaction with model lipid-based bacterial membranes (phosphatidylcholine/phosphatidylglycerol-based large unilamellar vesicles and sodium dodecylsulfate micelles) and helix inducing components (trifluoroethanol).
It was found that Hal-1 responds sensitively to the composition of the membrane model and to the peptide/lipid ratio.
The amphipathic nature of the helical Hal-1 seems to favour flat charged surfaces of the model lipid particles over the nondirectional interaction with trifluoroethanol.
Increasing fraction of polyproline II type conformation was detected at low peptide/lipid ratios.
American Psychological Association (APA)
Pazderková, Markéta& Kočišová, E.& Pazderka, Tomáš& Maloň, Petr& Kopecký Jr., Vladimír& Monincová, Lenka…[et al.]. 2012. Antimicrobial Peptide from the Eusocial Bee Halictus sexcinctus Interacting with Model Membranes. Journal of Spectroscopy،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1029361
Modern Language Association (MLA)
Pazderková, Markéta…[et al.]. Antimicrobial Peptide from the Eusocial Bee Halictus sexcinctus Interacting with Model Membranes. Journal of Spectroscopy No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-1029361
American Medical Association (AMA)
Pazderková, Markéta& Kočišová, E.& Pazderka, Tomáš& Maloň, Petr& Kopecký Jr., Vladimír& Monincová, Lenka…[et al.]. Antimicrobial Peptide from the Eusocial Bee Halictus sexcinctus Interacting with Model Membranes. Journal of Spectroscopy. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1029361
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029361