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Systemic Inflammatory Effects of Traumatic Brain Injury, Femur Fracture, and Shock: An Experimental Murine Polytrauma Model
Joint Authors
Mommsen, Philipp
Probst, C.
Mirzayan, M. J.
Tegeder, T.
Geerken, L.
Maegele, M.
Samii, A.
van Griensven, M.
Zeckey, Christian
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
Despite broad research in neurotrauma and shock, little is known on systemic inflammatory effects of the clinically most relevant combined polytrauma.
Experimental investigation in an animal model may provide relevant insight for therapeutic strategies.
We describe the effects of a combined injury with respect to lymphocyte population and cytokine activation.
Methods.
45 male C57BL/6J mice (mean weight 27 g) were anesthetized with ketamine/xylazine.
Animals were subjected to a weight drop closed traumatic brain injury (WD-TBI), a femoral fracture and hemorrhagic shock (FX-SH).
Animals were subdivided into WD-TBI, FX-SH and combined trauma (CO-TX) groups.
Subjects were sacrificed at 96 h.
Blood was analysed for cytokines and by flow cytometry for lymphocyte populations.
Results.
Mortality was 8%, 13% and 47% for FX-SH, WD-TBI and CO-TX groups (P<0.05).
TNFα (11/13/139 for FX-SH/WD-TBI/CO-TX; P<0.05), CCL2 (78/96/227; P<0.05) and IL-6 (16/48/281; P=0.05) showed significant increases in the CO-TX group.
Lymphocyte populations results for FX-SH, WD-TBI and CO-TX were: CD-4 (31/21/22; P= n.s.), CD-8 (7/28/34, P<0.05), CD-4-CD-8 (11/12/18; P= n.s.), CD-56 (36/7/8; P<0.05).
Conclusion.
This study shows that a combination of closed TBI and femur-fracture/ shock results in an increase of the humoral inflammation.
More attention to combined injury models in inflammation research is indicated.
American Psychological Association (APA)
Probst, C.& Mirzayan, M. J.& Mommsen, Philipp& Zeckey, Christian& Tegeder, T.& Geerken, L.…[et al.]. 2012. Systemic Inflammatory Effects of Traumatic Brain Injury, Femur Fracture, and Shock: An Experimental Murine Polytrauma Model. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029366
Modern Language Association (MLA)
Probst, C.…[et al.]. Systemic Inflammatory Effects of Traumatic Brain Injury, Femur Fracture, and Shock: An Experimental Murine Polytrauma Model. Mediators of Inflammation No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1029366
American Medical Association (AMA)
Probst, C.& Mirzayan, M. J.& Mommsen, Philipp& Zeckey, Christian& Tegeder, T.& Geerken, L.…[et al.]. Systemic Inflammatory Effects of Traumatic Brain Injury, Femur Fracture, and Shock: An Experimental Murine Polytrauma Model. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029366
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029366