Involvement of the Ubiquitin-Proteasome System in the Formation of Experimental Postsurgical Peritoneal Adhesions
Joint Authors
Canonico, Silvestro
Petronella, Pasquale
Di Filippo, Clara
Freda, Fulvio
Scorzelli, Marco
Ferretti, Marco
D'Amico, Michele
Rossi, Francesco
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We investigated the Ubiquitin-Proteasome System (UPS), major nonlysosomal intracellular protein degradation system, in the genesis of experimental postsurgical peritoneal adhesions.
We assayed the levels of UPS within the adhered tissue along with the development of peritoneal adhesions and used the specific UPS inhibitor bortezomib in order to assess the effect of the UPS blockade on the peritoneal adhesions.
We found a number of severe postsurgical peritoneal adhesions at day 5 after surgery increasing until day 10.
In the adhered tissue an increased values of ubiquitin and the 20S proteasome subunit, NFkB, IL-6, TNF-α and decreased values of IkB-beta were found.
In contrast, bortezomib-treated rats showed a decreased number of peritoneal adhesions, decreased values of ubiquitin and the 20S proteasome, NFkB, IL-6, TNF-α, and increased levels of IkB-beta in the adhered peritoneal tissue.
The UPS system, therefore, is primarily involved in the formation of post-surgical peritoneal adhesions in rats.
American Psychological Association (APA)
Di Filippo, Clara& Petronella, Pasquale& Freda, Fulvio& Scorzelli, Marco& Ferretti, Marco& Canonico, Silvestro…[et al.]. 2012. Involvement of the Ubiquitin-Proteasome System in the Formation of Experimental Postsurgical Peritoneal Adhesions. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029377
Modern Language Association (MLA)
Di Filippo, Clara…[et al.]. Involvement of the Ubiquitin-Proteasome System in the Formation of Experimental Postsurgical Peritoneal Adhesions. Mediators of Inflammation No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1029377
American Medical Association (AMA)
Di Filippo, Clara& Petronella, Pasquale& Freda, Fulvio& Scorzelli, Marco& Ferretti, Marco& Canonico, Silvestro…[et al.]. Involvement of the Ubiquitin-Proteasome System in the Formation of Experimental Postsurgical Peritoneal Adhesions. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029377
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029377