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L-Arginine and Asymmetric Dimethylarginine Are Early Predictors for Survival in Septic Patients with Acute Liver Failure
Joint Authors
Hofer, Stefan
Bierhaus, Angelika
Martin, Eike
Bruckner, Thomas
Nawroth, Peter P.
Krauser, Ute
Mieth, Markus
Weigand, Markus A.
Fleming, Thomas H.
Brenner, Thorsten
Rosenhagen, Claudia
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Dysfunctions of the L-arginine (L-arg)/nitric-oxide (NO) pathway are suspected to be important for the pathogenesis of multiple organ dysfunction syndrome (MODS) in septic shock.
Therefore plasma concentrations of L-arg and asymmetric dimethylarginine (ADMA) were measured in 60 patients with septic shock, 30 surgical patients and 30 healthy volunteers using enzyme linked immunosorbent assay (ELISA) kits.
Plasma samples from patients with septic shock were collected at sepsis onset, and 24 h, 4 d, 7 d, 14 d and 28 d later.
Samples from surgical patients were collected prior to surgery, immediately after the end of the surgical procedure as well as 24 h later and from healthy volunteers once.
In comparison to healthy volunteers and surgical patients, individuals with septic shock showed significantly increased levels of ADMA, as well as a decrease in the ratio of L-arg and ADMA at all timepoints.
In septic patients with an acute liver failure (ALF), plasma levels of ADMA and L-arg were significantly increased in comparison to septic patients with an intact hepatic function.
In summary it can be stated, that bioavailability of NO is reduced in septic shock.
Moreover, measurements of ADMA and L-arg appear to be early predictors for survival in patients with sepsis-associated ALF.
American Psychological Association (APA)
Brenner, Thorsten& Fleming, Thomas H.& Rosenhagen, Claudia& Krauser, Ute& Mieth, Markus& Bruckner, Thomas…[et al.]. 2012. L-Arginine and Asymmetric Dimethylarginine Are Early Predictors for Survival in Septic Patients with Acute Liver Failure. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1029380
Modern Language Association (MLA)
Brenner, Thorsten…[et al.]. L-Arginine and Asymmetric Dimethylarginine Are Early Predictors for Survival in Septic Patients with Acute Liver Failure. Mediators of Inflammation No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1029380
American Medical Association (AMA)
Brenner, Thorsten& Fleming, Thomas H.& Rosenhagen, Claudia& Krauser, Ute& Mieth, Markus& Bruckner, Thomas…[et al.]. L-Arginine and Asymmetric Dimethylarginine Are Early Predictors for Survival in Septic Patients with Acute Liver Failure. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1029380
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029380