Cigarette Smoke and Inflammation: Role in Cerebral Aneurysm Formation and Rupture
Joint Authors
Jabbour, Pascal M.
Dumont, Aaron S.
Gonzalez, L. Fernando
Ali, Muhammad S.
Rosenwasser, Robert H.
Koch, Walter J.
Chalouhi, Nohra
Starke, Robert M.
Tjoumakaris, Stavropoula I.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Smoking is an established risk factor for subarachnoid hemorrhage yet the underlying mechanisms are largely unknown.
Recent data has implicated a role of inflammation in the development of cerebral aneurysms.
Inflammation accompanying cigarette smoke exposure may thus be a critical pathway underlying the development, progression, and rupture of cerebral aneurysms.
Various constituents of the inflammatory response appear to be involved including adhesion molecules, cytokines, reactive oxygen species, leukocytes, matrix metalloproteinases, and vascular smooth muscle cells.
Characterization of the molecular basis of the inflammatory response accompanying cigarette smoke exposure will provide a rational approach for future targeted therapy.
In this paper, we review the current body of knowledge implicating cigarette smoke-induced inflammation in cerebral aneurysm formation/rupture and attempt to highlight important avenues for future investigation.
American Psychological Association (APA)
Chalouhi, Nohra& Ali, Muhammad S.& Starke, Robert M.& Jabbour, Pascal M.& Tjoumakaris, Stavropoula I.& Gonzalez, L. Fernando…[et al.]. 2012. Cigarette Smoke and Inflammation: Role in Cerebral Aneurysm Formation and Rupture. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1029385
Modern Language Association (MLA)
Chalouhi, Nohra…[et al.]. Cigarette Smoke and Inflammation: Role in Cerebral Aneurysm Formation and Rupture. Mediators of Inflammation No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-1029385
American Medical Association (AMA)
Chalouhi, Nohra& Ali, Muhammad S.& Starke, Robert M.& Jabbour, Pascal M.& Tjoumakaris, Stavropoula I.& Gonzalez, L. Fernando…[et al.]. Cigarette Smoke and Inflammation: Role in Cerebral Aneurysm Formation and Rupture. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1029385
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029385