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Danger Signals Activating the Immune Response after Trauma
Joint Authors
Werner, Clément M. L.
Rittirsch, Daniel
Hirsiger, Stefanie
Simmen, Hans-Peter
Wanner, Guido A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Sterile injury can cause a systemic inflammatory response syndrome (SIRS) that resembles the host response during sepsis.
The inflammatory response following trauma comprises various systems of the human body which are cross-linked with each other within a highly complex network of inflammation.
Endogenous danger signals (danger-associated molecular patterns; DAMPs; alarmins) as well as exogenous pathogen-associated molecular patterns (PAMPs) play a crucial role in the initiation of the immune response.
With popularization of the “danger theory,” numerous DAMPs and PAMPs and their corresponding pathogen-recognition receptors have been identified.
In this paper, we highlight the role of the DAMPs high-mobility group box protein 1 (HMGB1), interleukin-1α (IL-1α), and interleukin-33 (IL-33) as unique dual-function mediators as well as mitochondrial danger signals released upon cellular trauma and necrosis.
American Psychological Association (APA)
Hirsiger, Stefanie& Simmen, Hans-Peter& Werner, Clément M. L.& Wanner, Guido A.& Rittirsch, Daniel. 2012. Danger Signals Activating the Immune Response after Trauma. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1029388
Modern Language Association (MLA)
Hirsiger, Stefanie…[et al.]. Danger Signals Activating the Immune Response after Trauma. Mediators of Inflammation No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1029388
American Medical Association (AMA)
Hirsiger, Stefanie& Simmen, Hans-Peter& Werner, Clément M. L.& Wanner, Guido A.& Rittirsch, Daniel. Danger Signals Activating the Immune Response after Trauma. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1029388
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029388