Resolvin D1 Reduces the Immunoinflammatory Response of the Rat Eye following Uveitis
Joint Authors
Di Filippo, Clara
Settimio, Rossi
Franca, Ferraraccio
D'Amico, Michele
Simonelli, Francesca
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study investigated whether the administration of resolvin D1 to rats with endotoxininduced uveitis (EIU) ameliorates the immuno-inflammatory profile of the eye.
24 h after the administration of 200 μg LPS into the footpad of Sprague-Dawley rats, severe changes of the structure of the eye occurred concomitantly with a severe inflammatory and immune response.
These latter included strong infiltration of PMN leukocytes CD11b+ T-lymphocytes CD4+ and CD8+ within the eye and a significant release of the cytokines/chemokines TNF-alpha, CXCL8, and RANTES too.
Bolus of resolvin D1 (RvD1; 10–100–1000 ng/kg in 200 μL of sterile saline via the tail vein) significantly and dose-dependently (i) reduced the development of the ocular derangement caused by LPS; (ii) reduced the clinical score attributed to EIU; (iii) reduced the protein concentration and myeloperoxidase activity (MPO) in aqueous humor (AqH); and (iv) reduced neutrophils, T-lymphocytes, and cytokines within the eye.
American Psychological Association (APA)
Settimio, Rossi& Di Filippo, Clara& Franca, Ferraraccio& Simonelli, Francesca& D'Amico, Michele. 2012. Resolvin D1 Reduces the Immunoinflammatory Response of the Rat Eye following Uveitis. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1029390
Modern Language Association (MLA)
Settimio, Rossi…[et al.]. Resolvin D1 Reduces the Immunoinflammatory Response of the Rat Eye following Uveitis. Mediators of Inflammation No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1029390
American Medical Association (AMA)
Settimio, Rossi& Di Filippo, Clara& Franca, Ferraraccio& Simonelli, Francesca& D'Amico, Michele. Resolvin D1 Reduces the Immunoinflammatory Response of the Rat Eye following Uveitis. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1029390
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029390