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The Deleterious Influence of Tenofovir-Based Therapies on the Progression of Atherosclerosis in HIV-Infected Patients
Joint Authors
Beltrán-Debón, Raúl
Pardo-Reche, Pedro
Fernández-Sender, Laura
Rull, Anna
Joven, Jorge
Alonso-Villaverde, Carlos
Aragonès, Gerard
Camps, Jordi
Rodríguez-Gallego, Esther
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We investigated the potential differential effects of antiretroviral therapies on unbalanced chemokine homeostasis and on the progression of atherosclerosis in HIV-infected patients.
A two-year prospective study was performed in 67 consecutive HIV-infected patients initiating antiretroviral therapy with abacavir/lamivudine or tenofovir/emtricitabine.
Circulating levels of inflammatory biomarkers, progression of subclinical atherosclerosis and expression levels of selected chemokines genes in circulating leukocytes were assessed.
Control subjects showed significantly lower plasma concentrations of CRP, tPA, IL-6, and MCP-1 than HIV-infected patients at a baseline.
After two years of followup, the observed decreases in plasma inflammatory biomarker levels were only significant for MCP-1, tPA, and IL-6.
The decrease in plasma MCP-1 concentration was associated with the progression of atherosclerosis, and this effect was negligible only in patients receiving TDF-based therapy.
Multivariate analysis confirmed that treatment with TDF was positively and significantly associated with a higher likelihood of subclinical atherosclerosis progression.
However, the expression levels of selected genes in blood cells only showed associations with the viral load and total and HDL-cholesterol levels.
Current antiretroviral treatments may partially attenuate the influence of HIV infection on certain inflammatory pathways, though patients receiving TDF therapy must be carefully monitored with respect to the presence and/or progression of atherosclerosis.
American Psychological Association (APA)
Aragonès, Gerard& Pardo-Reche, Pedro& Fernández-Sender, Laura& Rull, Anna& Beltrán-Debón, Raúl& Rodríguez-Gallego, Esther…[et al.]. 2012. The Deleterious Influence of Tenofovir-Based Therapies on the Progression of Atherosclerosis in HIV-Infected Patients. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1029394
Modern Language Association (MLA)
Aragonès, Gerard…[et al.]. The Deleterious Influence of Tenofovir-Based Therapies on the Progression of Atherosclerosis in HIV-Infected Patients. Mediators of Inflammation No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1029394
American Medical Association (AMA)
Aragonès, Gerard& Pardo-Reche, Pedro& Fernández-Sender, Laura& Rull, Anna& Beltrán-Debón, Raúl& Rodríguez-Gallego, Esther…[et al.]. The Deleterious Influence of Tenofovir-Based Therapies on the Progression of Atherosclerosis in HIV-Infected Patients. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1029394
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029394