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Urinary Macrophage Migration Inhibitory Factor Serves as a Potential Biomarker for Acute Kidney Injury in Patients with Acute Pyelonephritis
Joint Authors
Hong, Ming-Yuan
Tseng, Chin-Chung
Chuang, Chia-Chang
Lin, Sheng-Hsiang
Lin, Chiou-Feng
Chen, Chia-Ling
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Conventional markers of kidney function that are familiar to clinicians, including the serum creatinine and blood urea nitrogen levels, are unable to reveal genuine injury to the kidney, and their use may delay treatment.
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine, and the predictive role and pathogenic mechanism of MIF deregulation during kidney infections involving acute kidney injury (AKI) are not currently known.
In this study, we showed that elevated urinary MIF levels accompanied the development of AKI during kidney infection in patients with acute pyelonephritis (APN).
In addition to the MIF level, the urinary levels of interleukin (IL)-1β and kidney injury molecule (KIM)-1 were also upregulated and were positively correlated with the levels of urinary MIF.
An elevated urinary MIF level, along with elevated IL-1β and KIM-1 levels, is speculated to be a potential biomarker for the presence of AKI in APN patients.
American Psychological Association (APA)
Hong, Ming-Yuan& Tseng, Chin-Chung& Chuang, Chia-Chang& Chen, Chia-Ling& Lin, Sheng-Hsiang& Lin, Chiou-Feng. 2012. Urinary Macrophage Migration Inhibitory Factor Serves as a Potential Biomarker for Acute Kidney Injury in Patients with Acute Pyelonephritis. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1029395
Modern Language Association (MLA)
Hong, Ming-Yuan…[et al.]. Urinary Macrophage Migration Inhibitory Factor Serves as a Potential Biomarker for Acute Kidney Injury in Patients with Acute Pyelonephritis. Mediators of Inflammation No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1029395
American Medical Association (AMA)
Hong, Ming-Yuan& Tseng, Chin-Chung& Chuang, Chia-Chang& Chen, Chia-Ling& Lin, Sheng-Hsiang& Lin, Chiou-Feng. Urinary Macrophage Migration Inhibitory Factor Serves as a Potential Biomarker for Acute Kidney Injury in Patients with Acute Pyelonephritis. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1029395
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029395