Inhibitory Effects of Pretreatment with Radon on Acute Alcohol-Induced Hepatopathy in Mice
Joint Authors
Yamaoka, Kiyonori
Nishiyama, Yuichi
Toyota, Teruaki
Taguchi, Takehito
Kataoka, Takahiro
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We previously reported that radon inhalation activates antioxidative functions in the liver and inhibits carbon tetrachloride-induced hepatopathy in mice.
In addition, it has been reported that reactive oxygen species contribute to alcohol-induced hepatopathy.
In this study, we examined the inhibitory effects of radon inhalation on acute alcohol-induced hepatopathy in mice.
C57BL/6J mice were subjected to intraperitoneal injection of 50% alcohol (5 g/kg bodyweight) after inhaling approximately 4000 Bq/m3 radon for 24 h.
Alcohol administration significantly increased the activities of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) in serum, and the levels of triglyceride and lipid peroxide in the liver, suggesting acute alcohol-induced hepatopathy.
Radon inhalation activated antioxidative functions in the liver.
Furthermore, pretreatment with radon inhibited the depression of hepatic functions and antioxidative functions.
These findings suggested that radon inhalation activated antioxidative functions in the liver and inhibited acute alcohol-induced hepatopathy in mice.
American Psychological Association (APA)
Toyota, Teruaki& Kataoka, Takahiro& Nishiyama, Yuichi& Taguchi, Takehito& Yamaoka, Kiyonori. 2012. Inhibitory Effects of Pretreatment with Radon on Acute Alcohol-Induced Hepatopathy in Mice. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1029396
Modern Language Association (MLA)
Toyota, Teruaki…[et al.]. Inhibitory Effects of Pretreatment with Radon on Acute Alcohol-Induced Hepatopathy in Mice. Mediators of Inflammation No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1029396
American Medical Association (AMA)
Toyota, Teruaki& Kataoka, Takahiro& Nishiyama, Yuichi& Taguchi, Takehito& Yamaoka, Kiyonori. Inhibitory Effects of Pretreatment with Radon on Acute Alcohol-Induced Hepatopathy in Mice. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1029396
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029396