![](/images/graphics-bg.png)
Disruption of the ECM33 Gene in Candida albicans Prevents Biofilm Formation, Engineered Human Oral Mucosa Tissue Damage and Gingival Cell NecrosisApoptosis
Joint Authors
Semlali, Abdelhabib
Chandra, Jyotsna
Mukherjee, Pranab
Chmielewski, Witold
Ghannoum, Mahmoud A.
Rouabhia, Mahmoud
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In this study we demonstrated that ΔCaecm33 double mutant showed reduced biofilm formation and causes less damage to gingival mucosa tissues.
This was confirmed by the reduced level of necrotic cells and Bax/Bcl2 gene expression as apoptotic markers.
In contrast, parental and Caecm33 mutant strains decreased basement membrane protein production (laminin 5 and type IV collagen).
We thus propose that ECM33 gene/protein represents a novel target for the prevention and treatment of infections caused by Candida.
American Psychological Association (APA)
Rouabhia, Mahmoud& Semlali, Abdelhabib& Chandra, Jyotsna& Mukherjee, Pranab& Chmielewski, Witold& Ghannoum, Mahmoud A.. 2012. Disruption of the ECM33 Gene in Candida albicans Prevents Biofilm Formation, Engineered Human Oral Mucosa Tissue Damage and Gingival Cell NecrosisApoptosis. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1029397
Modern Language Association (MLA)
Rouabhia, Mahmoud…[et al.]. Disruption of the ECM33 Gene in Candida albicans Prevents Biofilm Formation, Engineered Human Oral Mucosa Tissue Damage and Gingival Cell NecrosisApoptosis. Mediators of Inflammation No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1029397
American Medical Association (AMA)
Rouabhia, Mahmoud& Semlali, Abdelhabib& Chandra, Jyotsna& Mukherjee, Pranab& Chmielewski, Witold& Ghannoum, Mahmoud A.. Disruption of the ECM33 Gene in Candida albicans Prevents Biofilm Formation, Engineered Human Oral Mucosa Tissue Damage and Gingival Cell NecrosisApoptosis. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1029397
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029397