BAY 11-7082 Is a Broad-Spectrum Inhibitor with Anti-Inflammatory Activity against Multiple Targets
Joint Authors
Lee, Jaehwi
Kim, Eunji
Cho, Jae Youl
Rhee, Man Hee
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
BAY 11-7082 (BAY) is an inhibitor of κB kinase (IKK) that has pharmacological activities that include anticancer, neuroprotective, and anti-inflammatory effects.
In this study, BAY-pharmacological target pathways were further characterized to determine how this compound simultaneously suppresses various responses.
Primary and cancerous (RAW264.7 cells) macrophages were activated by lipopolysaccharide, a ligand of toll-like receptor 4.
As reported previously, BAY strongly suppressed the production of nitric oxide, prostaglandin E2, and tumor necrosis factor-α and reduced the translocation of p65, major subunit of nuclear factor-κB, and its upstream signaling events such as phosphorylation of IκBα, IKK, and Akt.
In addition, BAY also suppressed the translocation and activation of activator protein-1, interferon regulatory factor-3, and signal transducer and activator of transcription-1 by inhibiting the phosphorylation or activation of extracellular signal-related kinase, p38, TANK-binding protein, and Janus kinase-2.
These data strongly suggest that BAY is an inhibitor with multiple targets and could serve as a lead compound in developing strong anti-inflammatory drugs with multiple targets in inflammatory responses.
American Psychological Association (APA)
Lee, Jaehwi& Rhee, Man Hee& Kim, Eunji& Cho, Jae Youl. 2012. BAY 11-7082 Is a Broad-Spectrum Inhibitor with Anti-Inflammatory Activity against Multiple Targets. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1029399
Modern Language Association (MLA)
Lee, Jaehwi…[et al.]. BAY 11-7082 Is a Broad-Spectrum Inhibitor with Anti-Inflammatory Activity against Multiple Targets. Mediators of Inflammation No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1029399
American Medical Association (AMA)
Lee, Jaehwi& Rhee, Man Hee& Kim, Eunji& Cho, Jae Youl. BAY 11-7082 Is a Broad-Spectrum Inhibitor with Anti-Inflammatory Activity against Multiple Targets. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1029399
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029399